Department of Clinical and Experimental Medicine, University of Catania, Italy.
Lupus. 2018 Mar;27(3):507-510. doi: 10.1177/0961203317713144. Epub 2017 Jun 7.
Diffuse alveolar haemorrhage (DAH) is a rare life-threatening complication of systemic lupus erythematosus (SLE), associated with high mortality rates. It usually occurs in patients with an established diagnosis of SLE. It has been reported as the initial presentation of SLE in 11-20% of cases. It occurs most frequently in females. We describe the case of a child, aged 14 years, with fever, asthenia, haemoptysis, dyspnea, anaemia, increased inflammatory markers, positivity to ANA, nDNA, direct Coombs tests, anticardiolipin antibodies and complement factors consumption. Computed tomography (CTscan) of the chest showed bilateral pulmonary alveolar infiltrates. He also developed renal involvement with nephritis later in the course of the disease. He was started on the treatment approved by the Euro Lupus Protocol for critical patients. After starting Mycophenolate Mofetil the clinical and radiological features were improved as was the survival outcome.
弥漫性肺泡出血（DAH）是系统性红斑狼疮（SLE）的一种罕见的危及生命的并发症，与高死亡率相关。它通常发生在已确诊的 SLE 患者中。据报道，在 11-20%的病例中，它是 SLE 的初始表现。它最常发生在女性中。我们描述了一例 14 岁的儿童，他有发热、乏力、咯血、呼吸困难、贫血、炎症标志物升高、抗核抗体、双链 DNA、直接 Coombs 试验、抗心磷脂抗体和补体因子消耗阳性。胸部计算机断层扫描（CT 扫描）显示双侧肺泡浸润。在疾病过程中，他还出现了肾脏受累，表现为肾炎。他开始接受 Euro Lupus 协议批准的危重症患者治疗。开始使用霉酚酸酯后，临床和影像学特征得到改善，生存结果也得到改善。
