Universidade de Sorocaba, Sorocaba, SP, Brazil.
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Biol Trace Elem Res. 2018 Mar;182(1):70-77. doi: 10.1007/s12011-017-1076-1. Epub 2017 Jun 20.
Selenium (Se) is an essential trace element involved in several biological pathways, naturally found in rocks, soils, and food. Even though the daily requirement of Se is achieved through a balanced diet, the use of Se supplements has been frequent. Due to the risk of toxic effects of having Se in excess, supplementation is still under debate. The aim was to evaluate the effects of long-term Se supplementation upon systolic blood pressure (SBP) and redox status of rats exposed to sodium selenite. Male Wistar rats were exposed to 2 and 6 mg/L of sodium selenite in drinking water for 85 days. SBP and body weight were evaluated weekly; oxidative stress biomarkers were measured in blood or plasma; and Se levels were assessed in blood, plasma, kidney, and liver. Se supplementation (2 and 6 mg/L) induced significant increase in the SBP in rats from the 42nd day until the end of the study. This increase on SBP was not associated with significant changes in oxidative stress biomarkers. A significant increase in Se levels was found in whole blood, kidney, and liver from both groups of rats receiving Se supplementation when compared to control. Although the exact mechanisms underlying this augment in SBP are not clear, they are potentially related to other Se biological routes besides the synthesis of selenoproteins, such as GSH-Px. Due to the negative effects upon blood pressure, precautionary measures are advised, since the selling of supplements does not require a medical prescription.
硒（Se）是一种参与多种生物途径的必需微量元素，天然存在于岩石、土壤和食物中。尽管通过均衡饮食可以满足人体对硒的日常需求，但人们仍频繁使用硒补充剂。由于硒过量存在的毒性作用的风险，补充剂的使用仍存在争议。本研究旨在评估长期补充硒对暴露于亚硒酸钠的大鼠的收缩压（SBP）和氧化还原状态的影响。雄性 Wistar 大鼠在饮用水中分别暴露于 2 和 6mg/L 的亚硒酸钠，持续 85 天。每周评估 SBP 和体重；在血液或血浆中测量氧化应激生物标志物；并评估血液、血浆、肾脏和肝脏中的硒水平。硒补充剂（2 和 6mg/L）在研究的第 42 天至结束时诱导大鼠的 SBP 显著升高。这种 SBP 的升高与氧化应激生物标志物的显著变化无关。与对照组相比，接受硒补充剂的两组大鼠的全血、肾脏和肝脏中的硒水平均显著升高。尽管 SBP 升高的确切机制尚不清楚，但它们可能与除了合成硒蛋白以外的其他硒生物途径有关，例如 GSH-Px。由于对血压的负面影响，建议采取预防措施，因为销售补充剂不需要医生处方。
