Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts, 02467, USA.
Small. 2017 Aug;13(32). doi: 10.1002/smll.201700880. Epub 2017 Jun 22.
Owing to the progressive development of metal-organic-frameworks (MOFs) synthetic processes and considerable potential applications in last decade, integrating biomolecules into MOFs has recently gain considerable attention. Biomolecules, including lipids, oligopeptides, nucleic acids, and proteins have been readily incorporated into MOF systems via versatile formulation methods. The formed biomolecule-MOF hybrid structures have shown promising prospects in various fields, such as antitumor treatment, gene delivery, biomolecular sensing, and nanomotor device. By optimizing biomolecule integration methods while overcoming existing challenges, biomolecule-integrated MOF platforms are very promising to generate more practical applications.
由于金属-有机骨架（MOFs）合成工艺的不断发展和过去十年中相当多的潜在应用，将生物分子整合到 MOFs 中最近引起了相当大的关注。生物分子，包括脂质、寡肽、核酸和蛋白质，已经通过多种制剂方法很容易地被整合到 MOF 体系中。形成的生物分子-MOF 杂化结构在抗肿瘤治疗、基因传递、生物分子传感和纳米马达装置等各个领域都显示出了广阔的前景。通过优化生物分子整合方法，同时克服现有挑战，生物分子整合的 MOF 平台非常有希望产生更多的实际应用。
