Qiao Jing, Duan Jinyu, Zhang Yong, Chu Yi, Sun Changzhou
Department of Periodontology, Outpatient Center, Peking University School & Hospital of Stomatology, Beijing, China.
Future Sci OA. 2016 Sep 15;2(4):FS136. doi: 10.4155/fsoa-2016-0019. eCollection 2016 Dec.
To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.
Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.
No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001).
Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.
探讨浓缩生长因子（CGFs）在人类骨内缺损治疗中的作用。
31例骨内缺损患者被随机分为两组，分别接受CGFs + 牛多孔骨矿物质（BPBM）治疗或单纯BPBM治疗。在基线和术后1年评估探诊深度、临床附着水平和硬组织填充情况。
基线时，各研究参数均无差异。治疗1年后，两组临床参数均有显著改善（p < 0.001）。CGFs + BPBM组在降低探诊深度（4.2 ± 1.3 mm vs 3.0 ± 1.6 mm）和增加临床附着水平（3.7 ± 1.3 mm vs 2.4 ± 1.1 mm；p ≤ 0.05）方面比单纯BPBM组更有效。与BPBM组相比，CGFs + BPBM组硬组织填充有良好增加（p > 0.05）。CGFs中生长因子的含量在统计学上高于血小板贫乏血浆中的含量（p < 0.001）。
添加CGFs显著提高了BPBM治疗骨内缺损的临床疗效。
