浓缩生长因子在治疗牙周骨内缺损中的作用。
The effect of concentrated growth factors in the treatment of periodontal intrabony defects.
作者信息
Qiao Jing, Duan Jinyu, Zhang Yong, Chu Yi, Sun Changzhou
机构信息
Department of Periodontology, Outpatient Center, Peking University School & Hospital of Stomatology, Beijing, China.
出版信息
Future Sci OA. 2016 Sep 15;2(4):FS136. doi: 10.4155/fsoa-2016-0019. eCollection 2016 Dec.
AIM
To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.
METHODS
Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.
RESULTS
No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001).
CONCLUSION
Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.
目的
探讨浓缩生长因子（CGFs）在人类骨内缺损治疗中的作用。
方法
31例骨内缺损患者被随机分为两组，分别接受CGFs + 牛多孔骨矿物质（BPBM）治疗或单纯BPBM治疗。在基线和术后1年评估探诊深度、临床附着水平和硬组织填充情况。
结果
基线时，各研究参数均无差异。治疗1年后，两组临床参数均有显著改善（p < 0.001）。CGFs + BPBM组在降低探诊深度（4.2 ± 1.3 mm vs 3.0 ± 1.6 mm）和增加临床附着水平（3.7 ± 1.3 mm vs 2.4 ± 1.1 mm；p ≤ 0.05）方面比单纯BPBM组更有效。与BPBM组相比，CGFs + BPBM组硬组织填充有良好增加（p > 0.05）。CGFs中生长因子的含量在统计学上高于血小板贫乏血浆中的含量（p < 0.001）。
结论
添加CGFs显著提高了BPBM治疗骨内缺损的临床疗效。
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