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J Clin Microbiol. 1985 Dec;22(6):940-4. doi: 10.1128/jcm.22.6.940-944.1985.
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本文引用的文献

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Hantaan virus: identification of virion proteins.汉坦病毒：病毒粒子蛋白的鉴定
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Evaluation of focus reduction neutralization test with peroxidase-antiperoxidase staining technique for hemorrhagic fever with renal syndrome virus.
J Clin Microbiol. 1984 Dec;20(6):1213-5. doi: 10.1128/jcm.20.6.1213-1215.1984.
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Hantaan-like viruses from domestic rats captured in the United States.从美国捕获的家鼠身上发现的汉坦病毒样病毒。
Am J Trop Med Hyg. 1984 Sep;33(5):992-8. doi: 10.4269/ajtmh.1984.33.992.
4
Prospect Hill virus: serologic evidence for infection in mammalogists.展望山病毒：哺乳动物学家感染的血清学证据。
N Engl J Med. 1984 May 17;310(20):1325-6. doi: 10.1056/NEJM198405173102013.
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Isolation and propagation of nephropathia epidemica virus in bank voles.流行性肾病病毒在棕背䶄中的分离与增殖
Scand J Infect Dis. 1984;16(3):225-8. doi: 10.3109/00365548409070393.
6
Determination by immune adherence HA of the antigenic relationship between Rattus- and Apodemus-borne viruses causing hemorrhagic fever with renal syndrome.用免疫粘附血凝试验确定家鼠型和姬鼠型肾综合征出血热病毒之间的抗原关系
J Infect Dis. 1984 Mar;149(3):472. doi: 10.1093/infdis/149.3.472.
7
Antigenic difference between European and East Asian viruses causing haemorrhagic fever with renal syndrome.导致肾综合征出血热的欧洲病毒和东亚病毒之间的抗原差异。
Lancet. 1981 Aug 1;2(8240):256-7. doi: 10.1016/s0140-6736(81)90505-5.
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Propagation of nephropathia epidemica virus in cell culture.流行性肾病病毒在细胞培养中的增殖
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9
Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area.在非疫区从城市大鼠中分离出一种与肾综合征出血热相关的病毒。
J Infect Dis. 1984 Mar;149(3):473. doi: 10.1093/infdis/149.3.473.
10
An immune adherence assay for discrimination between etiologic agents of hemorrhagic fever with renal syndrome.一种用于区分肾综合征出血热病原体的免疫黏附试验。
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通过间接免疫荧光抗体和空斑减少中和试验对汉坦病毒进行血清型分类。

Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests.

作者信息

Lee P W, Gibbs C J, Gajdusek D C, Yanagihara R

出版信息

J Clin Microbiol. 1985 Dec;22(6):940-4. doi: 10.1128/jcm.22.6.940-944.1985.

DOI:10.1128/jcm.22.6.940-944.1985
PMID:2866197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC271855/
Abstract

Antisera prepared against 16 strains of hantaviruses isolated from patients with hemorrhagic fever with renal syndrome (HFRS) or from rodents captured in HFRS-endemic and nonendemic regions were titrated against Hantaan virus strain 76-118, Puumala virus strain Sotkamo, and Prospect Hill virus strain Prospect Hill-I by using the indirect immunofluorescent antibody and plaque reduction neutralization tests. Isolates fell into one of four distinct groups or serotypes. Serotype 1 included Apodemus-derived strains, serotype 2 included Rattus-derived strains, serotype 3 included Clethrionomys-derived strains, and serotype 4 included Microtus-derived strains. Serotypic classification of hantavirus infections was possible for humans and rodents in widely varied geographical areas, but in a few instances, sera from patients with HFRS did not conform to any of the four serotypes, suggesting the existence of as yet unidentified serotypes. A definitive serological classification of hantaviruses must await analysis of additional virus isolates.

摘要

用间接免疫荧光抗体和蚀斑减少中和试验，对从肾综合征出血热（HFRS）患者或从HFRS流行区和非流行区捕获的啮齿动物中分离出的16株汉坦病毒制备的抗血清，进行针对汉滩病毒76-118株、普马拉病毒索特卡莫株和展望山病毒展望山-Ⅰ株的滴定。分离株分为四个不同的组或血清型之一。血清型1包括姬鼠属来源的毒株，血清型2包括大鼠属来源的毒株，血清型3包括棕背䶄属来源的毒株，血清型4包括田鼠属来源的毒株。在广泛不同的地理区域，对人类和啮齿动物的汉坦病毒感染进行血清型分类是可能的，但在少数情况下，HFRS患者的血清不符合四种血清型中的任何一种，这表明存在尚未鉴定的血清型。汉坦病毒的明确血清学分类必须等待对更多病毒分离株的分析。