Israel Plant Gene Bank, ARO Volcani Center, Rishon LeZion, Israel.
Institute of Plant Sciences, Agriculture Research Organization, Volcani Center, Rishon LeZion, Israel.
Curr Med Chem. 2018;25(36):4656-4670. doi: 10.2174/0929867324666170705113129.
The Mediterranean basin is one of the richest biodiversity areas in the world, and the use of medicinal plants for treating cancer in this area has been documented for generations in different cultures.
To present and discuss the findings related to medicinal plants with confirmed data on active compounds and/or clear mode of action.
We undertook a structured search of bibliography of peer-reviewed research literature using key words and a focused review question. Papers with sufficient quality were reviewed, their findings presented and integrated into a coherent, state of the art document on wild plants of the Middle East with anti-cancer activity.
121 papers were included in the review, among them 10 define herbal medicine, 3 describe the status of cancer worldwide, 18 discuss biodiversity, chemodiversity, ethnopharmacological survey and conservation of medicinal plants, 12 describe well known natural products from plants used to treat cancer and 78 papers describe specific compounds and mode of action in different wild plants from the middle east, traditionally used to treat cancer.
Confirmed data on active compounds and/or clear mode of action exist for several wild plants traditionally used in herbal medicine to treat cancer. Yet, medicinal plants were mainly gathered from the wild, resulting in some of the commonly used herbs becoming endangered species. Also, in many cases, the activity and biochemical profile of plants harvested over different time spans and ecosystems may vary. Rational cultivation may ensure optimized yield with a uniform high quality of products.
地中海盆地是世界上生物多样性最丰富的地区之一，不同文化世代以来一直有使用药用植物治疗癌症的记载。
介绍和讨论与药用植物相关的发现，这些植物具有已确认的活性化合物数据和/或明确的作用模式。
我们使用关键词和重点审查问题，对同行评议研究文献的书目进行了结构化搜索。对具有足够质量的论文进行了审查，呈现并整合了它们的发现，形成了一份关于具有抗癌活性的中东野生植物的最新、全面的文件。
综述共纳入了 121 篇论文，其中 10 篇定义了草药医学，3 篇描述了全球癌症的现状，18 篇讨论了生物多样性、化学多样性、药用植物的民族药理学调查和保护，12 篇描述了用于治疗癌症的知名植物天然产物，78 篇描述了传统上用于治疗癌症的中东野生植物的特定化合物和作用模式。
几种传统上用于草药医学治疗癌症的野生植物具有已确认的活性化合物和/或明确的作用模式的数据。然而，药用植物主要是从野外采集的，导致一些常用草药成为濒危物种。此外，在许多情况下，在不同时间跨度和生态系统中收获的植物的活性和生化特征可能会有所不同。合理的栽培可以确保优化产量，并具有一致的高质量产品。
