Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany.
Department of Chemistry, College of Natural Sciences, Jimma University, P.O. Box 378, 251 Jimma, Ethiopia.
Molecules. 2017 Jul 7;22(7):1136. doi: 10.3390/molecules22071136.
Phytochemical investigation of the ethyl acetate extract of the roots of led to the isolation of four new natural products-1,8-dimethoxynepodinol (), aloesaponarin III (), 10--methylchrysalodin () and methyl-26--feruloyl-oxyhexacosanate ()-along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC = 0.98 µM) being the most active compound.
从 led 的根的乙酸乙酯提取物中进行植物化学研究，分离得到了四个新的天然产物-1,8-二甲氧基新菠萝酚（）、芦荟皂素 III（）、10--甲基 chrysalodin（）和甲基-26--阿魏酰氧基十六烷酸酯（）-以及十个已知的化合物。所有纯化的代谢产物均通过 NMR、质谱分析和与文献数据的比较进行了表征。对这些分离物进行了人宫颈癌细胞系 KB-3-1 的细胞毒性活性评价，其中一些化合物表现出良好的活性，芦荟皂素 II（IC = 0.98 µM）是最具活性的化合物。
