Zempleni Janos
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE USA.
Genes Nutr. 2017 Jun 22;12:12. doi: 10.1186/s12263-017-0562-6. eCollection 2017.
Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line of research is slowed by a controversy whether the delivery and bioactivity of a single class of vesicle cargos, microRNAs, are real or not. This opinion paper argues that the evidence in support of the bioavailability of microRNAs encapsulated in dietary exosomes outweighs the evidence produced by scholars doubting that phenomenon is real. Importantly, this paper posits that the time is ripe to look beyond microRNA cargos and pursue innovative pathways through which dietary exosomes alter metabolism. Here, we highlight potentially fruitful lines of exploration.
细胞外囊泡可将多种货物递送至受体细胞，包括将牛乳饮食性囊泡中的货物递送至非牛物种的细胞。在这一重要研究领域，由于对于一类囊泡货物——微小RNA的递送及生物活性是否真实存在存在争议，发现速度有所放缓。这篇观点论文认为，支持饮食外泌体中包裹的微小RNA具有生物利用度的证据，比怀疑该现象真实性的学者所提供的证据更具说服力。重要的是，本文认为，现在是时候超越微小RNA货物，探索饮食外泌体改变新陈代谢的创新途径了。在此，我们强调了一些可能富有成果的探索方向。
