噬菌体Mu及其他转座元件转座与复制的分子模型。
Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements.
作者信息
Shapiro J A
出版信息
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1933-7. doi: 10.1073/pnas.76.4.1933.
Abstract
A series of molecular events will explain how genetic elements can transpose from one DNA site to another, generate a short oligonucleotide duplication at both ends of the new insertion site, and replicate in the transposition process. These events include the formation of recombinant molecules which have been postulated to be intermediates in the transposition process. The model explains how the replication of bacteriophage Mu is obligatorily associated with movement to new genetic sites. It postulates that all transposable elements replicate in the transposition process so that they remain at their original site while moving to new sites. According to this model, the mechanism of transposition is very different from the insertion and excision of bacteriophage lambda.
摘要
一系列分子事件将解释遗传元件如何从一个DNA位点转移到另一个位点，在新插入位点的两端产生短的寡核苷酸重复，并在转座过程中进行复制。这些事件包括重组分子的形成，这些重组分子被假定为转座过程中的中间体。该模型解释了噬菌体Mu的复制如何必然与向新的遗传位点移动相关联。它假定所有转座元件在转座过程中进行复制，以便它们在移动到新位点时仍保留在其原始位点。根据这个模型，转座机制与噬菌体λ的插入和切除非常不同。
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