Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Cell Biochem. 2018 Feb;119(2):1291-1298. doi: 10.1002/jcb.26303. Epub 2017 Aug 28.
Generating plants with increased yields while maintaining low production and maintenance costs is highly important since plants are the major food source for humans and animals, as well as important producers of chemicals, pharmaceuticals, and fuels. Gene editing approaches, particularly the CRISPR-Cas system, are the preferred methods for improving crops, enabling quick, robust, and accurate gene manipulation. Nevertheless, new breeds of genetically modified crops have initiated substantial debates concerning their biosafety, commercial use, and regulation. Here, we discuss the challenges facing genetic engineering of crops by CRISPR-cas, and highlight the pros and cons of using this tool.
培育产量高、生产成本和维护成本低的植物非常重要，因为植物是人类和动物的主要食物来源，也是化学品、药品和燃料的重要生产者。基因编辑方法，特别是 CRISPR-Cas 系统，是改良作物的首选方法，能够快速、稳健、准确地进行基因操作。然而，新型转基因作物引发了关于其生物安全性、商业用途和监管的大量争论。在这里，我们讨论了 CRISPR-cas 对作物遗传工程面临的挑战，并强调了使用该工具的优缺点。
