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以壳寡糖为模板合成生物相容性羟基磷灰石

Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template.

作者信息

Wang Jinyu, Liu Guanxiong, Chen Jinshuai, Zhao Bo, Zhu Peizhi

机构信息

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.

出版信息

Materials (Basel). 2015 Nov 30;8(12):8097-8105. doi: 10.3390/ma8125440.

DOI:10.3390/ma8125440
PMID:28793700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5458867/
Abstract

In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications.

摘要

在本研究中，以壳寡糖（COS）为模板合成了一种新型生物相容性羟基磷灰石（HA）。通过傅里叶变换红外（FTIR）光谱、X射线衍射（XRD）、X射线光电子能谱（XPS）和透射电子显微镜（TEM）对这些HA样品进行了研究。通过MG-63细胞系的细胞活力、细胞形态和碱性磷酸酶染色评估了HA样品的生物相容性。结果表明，在COS存在下合成的HA有利于MG-63细胞的增殖和成骨分化。这些羟基磷灰石是骨组织工程应用中具有潜在吸引力的生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/01f284b70203/materials-08-05440-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/3f615ffd6d7b/materials-08-05440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/d3ada6b2cd50/materials-08-05440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/1abeecd8970b/materials-08-05440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/616d74ac003b/materials-08-05440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/f6eed74b06af/materials-08-05440-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/33b07da96497/materials-08-05440-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/01f284b70203/materials-08-05440-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/3f615ffd6d7b/materials-08-05440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/d3ada6b2cd50/materials-08-05440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/1abeecd8970b/materials-08-05440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/616d74ac003b/materials-08-05440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/f6eed74b06af/materials-08-05440-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/33b07da96497/materials-08-05440-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e0/5458867/01f284b70203/materials-08-05440-g007.jpg

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