Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia.
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia.
Curr Opin Biotechnol. 2018 Feb;49:42-48. doi: 10.1016/j.copbio.2017.07.009. Epub 2017 Aug 11.
In this review, we present the latest developments in plant systems biology with particular emphasis on plant genome-scale reconstructions and multi-omics analyses. Understanding multicellular metabolism is far from trivial and 'omics' data are difficult to interpret in the absence of a systems framework. 'Omics' data appropriately integrated with genome-scale reconstructions and modelling facilitates our understanding of how individual components interact and influence overall cell, tissue or organisms function. Here we present examples of how plant metabolic reconstructions and modelling are used as a systems-based framework for improving our understanding of the plant metabolic processes in single cells and multiple tissues.
在这篇综述中，我们介绍了植物系统生物学的最新进展，特别强调了植物基因组规模的重建和多组学分析。理解多细胞代谢远非易事，在缺乏系统框架的情况下，“组学”数据很难解释。将“组学”数据与基因组规模的重建和建模适当整合，有助于我们理解单个组件如何相互作用并影响整个细胞、组织或生物体的功能。在这里，我们展示了植物代谢重建和建模如何作为一个基于系统的框架，用于提高我们对单细胞和多个组织中植物代谢过程的理解的例子。
