主要组织相容性复合体区域基因对日本冲绳百岁老人和九旬老人人群中人类长寿的影响。

Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians.

作者信息

Takata H, Suzuki M, Ishii T, Sekiguchi S, Iri H

机构信息

Department of Clinical Laboratories, Keio University School of Medicine, Tokyo, Japan.

出版信息

Lancet. 1987 Oct 10;2(8563):824-6. doi: 10.1016/s0140-6736(87)91015-4.

DOI:10.1016/s0140-6736(87)91015-4

PMID:2889033

Abstract

The frequencies of 80 HLA antigen phenotypes in 82 centenarians and 20 nonagenarians in Okinawa, Japan, were compared with those in other healthy adults in various age-brackets. Subjects aged over 90 had an extremely low frequency of HLA-DRw9 and an increased frequency of DR1. In this age-group the relative risk of corrected (for number of antigens) p value for HLA-DRw9 were 5.2 and 0.0001, respectively; those for HLA-DR1 were 13.3 and 0.0367, respectively. Since a high frequency of DRw9 and a low frequency of DR1 are associated with autoimmune or immune deficiency diseases, the genetic protection against these disorders may contribute to longevity.

摘要

对日本冲绳82名百岁老人和20名九旬老人的80种HLA抗原表型频率，与其他各年龄段健康成年人的频率进行了比较。90岁以上的受试者HLA - DRw9频率极低，而DR1频率增加。在这个年龄组中，针对HLA - DRw9校正后的（针对抗原数量）p值的相对风险分别为5.2和0.0001；针对HLA - DR1的相对风险分别为13.3和0.0367。由于DRw9的高频率和DR1的低频率与自身免疫性或免疫缺陷疾病相关，针对这些疾病的遗传保护可能有助于长寿。