Takata H, Suzuki M, Ishii T, Sekiguchi S, Iri H
Department of Clinical Laboratories, Keio University School of Medicine, Tokyo, Japan.
Lancet. 1987 Oct 10;2(8563):824-6. doi: 10.1016/s0140-6736(87)91015-4.
The frequencies of 80 HLA antigen phenotypes in 82 centenarians and 20 nonagenarians in Okinawa, Japan, were compared with those in other healthy adults in various age-brackets. Subjects aged over 90 had an extremely low frequency of HLA-DRw9 and an increased frequency of DR1. In this age-group the relative risk of corrected (for number of antigens) p value for HLA-DRw9 were 5.2 and 0.0001, respectively; those for HLA-DR1 were 13.3 and 0.0367, respectively. Since a high frequency of DRw9 and a low frequency of DR1 are associated with autoimmune or immune deficiency diseases, the genetic protection against these disorders may contribute to longevity.
对日本冲绳82名百岁老人和20名九旬老人的80种HLA抗原表型频率，与其他各年龄段健康成年人的频率进行了比较。90岁以上的受试者HLA - DRw9频率极低，而DR1频率增加。在这个年龄组中，针对HLA - DRw9校正后的（针对抗原数量）p值的相对风险分别为5.2和0.0001；针对HLA - DR1的相对风险分别为13.3和0.0367。由于DRw9的高频率和DR1的低频率与自身免疫性或免疫缺陷疾病相关，针对这些疾病的遗传保护可能有助于长寿。
