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一例因自行服用杏仁提取物导致慢性氰化物中毒的罕见病例。

An unusual presentation of chronic cyanide toxicity from self-prescribed apricot kernel extract.

作者信息

Konstantatos Alex, Shiv Kumar Malini, Burrell Aidan, Smith Joel

机构信息

Departments of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia.

出版信息

BMJ Case Rep. 2017 Sep 11;2017:bcr-2017-220814. doi: 10.1136/bcr-2017-220814.

Abstract

Hypoxia under general anaesthesia is a potentially life-threatening condition. A seemingly well 67-year-old man appeared hypoxic with peripheral pulse oximetric measurement during routine anaesthesia. Postoperatively, the patient admitted to daily self-prescription of apricot kernel extract for a period of 5 years. Apricot kernel is a commonly taken extract used for a range of ailments, and is associated with cyanide toxicity, which was confirmed through blood analysis. Our explanation for the hypoxic measurement was the presence of free cyanide interfering with functioning of the peripheral pulse oximeter. On cessation of the apricot kernel extract, peripheral oxygen saturations returned to normal. Cardiac and respiratory causes together with rare haemoglobinopathies were excluded. This case illustrates how chronic dosing of complementary medicines can result in harmful toxicities, which may carry potential for serious consequences and how these chronic toxicities may present to physicians in atypical ways.

摘要

全身麻醉下的低氧血症是一种潜在的危及生命的状况。一名看似健康的67岁男性在常规麻醉期间经外周脉搏血氧饱和度测量显示为低氧状态。术后,患者承认有5年的时间每天自行服用杏仁提取物。杏仁是一种常用于多种疾病的提取物,与氰化物中毒有关,血液分析证实了这一点。我们对低氧测量结果的解释是游离氰化物的存在干扰了外周脉搏血氧仪的功能。停止服用杏仁提取物后,外周血氧饱和度恢复正常。排除了心脏和呼吸方面的原因以及罕见的血红蛋白病。该病例说明了长期服用补充药物如何导致有害毒性,这可能带来严重后果,以及这些慢性毒性如何以非典型方式呈现给医生。

相似文献

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Apricot kernels: a rare case of cyanide toxicity.杏仁:一例罕见的氰化物中毒病例。
Emerg Med Australas. 2015 Oct;27(5):491-2. doi: 10.1111/1742-6723.12462. Epub 2015 Aug 20.
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Cyanide poisoning caused by ingestion of apricot seeds.因食用杏仁种子导致的氰化物中毒。
Ann Trop Paediatr. 2010;30(1):39-43. doi: 10.1179/146532810X12637745451951.

本文引用的文献

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Pulse oximetry and genetic hemoglobinopathies.脉搏血氧测定法与遗传性血红蛋白病
Intensive Care Med. 2005 Nov;31(11):1597; author reply 1598. doi: 10.1007/s00134-005-2797-8. Epub 2005 Aug 27.
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