Biomedical Engineering and ‡Material Science and Engineering, Dwight Look College of Engineering, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States.
Langmuir. 2018 Jan 23;34(3):917-925. doi: 10.1021/acs.langmuir.7b02540. Epub 2017 Oct 25.
Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Laponite) and poly(ethylene glycol) (PEG). The addition of Laponite reinforces the PEG network and increases viscosity, storage modulus, and network stability. PEG-Laponite hydrogels display shear-thinning and self-recovery characteristics due to rapid internal phase rearrangement. As a result, a range of complex patterns can be printed using PEG-Laponite bioinks. The 3D bioprinted structure has similar mechanical properties compared to the as-casted structure. In addition, encapsulated cells within the PEG-Laponite bioink show high viability after bioprinting. Overall, this study introduces a new class of PEG-Laponite colloidal inks for bioprinting and cell delivery.
纳米工程水凝胶为设计用于三维（3D）生物打印的剪切稀化生物墨水提供了可能。在这里，我们合成了由圆盘状二维（2D）纳米硅酸盐（Laponite）和聚乙二醇（PEG）组成的胶体生物墨水。添加 Laponite 增强了 PEG 网络并增加了粘度、储能模量和网络稳定性。PEG-Laponite 水凝胶由于快速的内部相重排而表现出剪切稀化和自恢复特性。结果，使用 PEG-Laponite 生物墨水可以打印出各种复杂的图案。3D 生物打印结构与铸造结构具有相似的机械性能。此外，封装在 PEG-Laponite 生物墨水中的细胞在生物打印后具有高活力。总的来说，这项研究为生物打印和细胞输送引入了一类新的 PEG-Laponite 胶体墨水。
