Honda K, Ishizaki K, Ikenaga M, Toguchida J, Inamoto T, Tanaka K, Ozawa K
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Hum Genet. 1988 Aug;79(4):297-300. doi: 10.1007/BF00282164.
We have examined the c-Ha-ras locus in 145 cancer patients of a mixed group and 164 normal individuals in Japan for restriction fragment length polymorphisms and compared the allele distributions in normal and cancer populations. The c-Ha-ras gene is highly polymorphic in Japanese as previously reported in Caucasians. Two rare alleles were found to be present with increased frequencies in Japanese cancer patients. These results suggest that genotype analysis of the c-Ha-ras gene could be used to detect cancer-prone individuals.
我们在日本的145名混合组癌症患者和164名正常个体中检测了c-Ha-ras基因座的限制性片段长度多态性，并比较了正常人群和癌症人群中的等位基因分布。如先前在高加索人中所报道的那样，c-Ha-ras基因在日本人中具有高度多态性。发现两种罕见等位基因在日本癌症患者中的频率有所增加。这些结果表明，c-Ha-ras基因的基因型分析可用于检测易患癌症的个体。
