紫苏籽油对高脂血症大鼠血脂、氧化应激及炎症的影响

Effects of Perilla Seed Oil on Blood Lipids, Oxidative Stress, and Inflammation in Hyperlipidemic Rats.

作者信息

Pothinam Suwajee, Putpim Chaochetdhapada, Siriwoharn Thanyaporn, Jirarattanarangsri Wachira

机构信息

Division of Food Science and Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.

Laboratory Animal Center, Office of Research Administration, Chiang Mai University, Chiang Mai 50100, Thailand.

出版信息

Foods. 2025 Apr 17;14(8):1380. doi: 10.3390/foods14081380.

DOI:10.3390/foods14081380

PMID:40282780

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12026981/

Abstract

A high-fat diet is a key factor contributing to hyperlipidemia. Perilla seed oil, a plant-based source of omega-3, has the potential to reduce this risk. However, its effects have not been fully established. This study aimed to evaluate the effects of perilla seed oil on blood lipid levels, oxidative stress, and inflammation in rats induced with hyperlipidemia through a high-fat diet. Male Wistar rats were administered perilla seed oil at a dosage of 0.67 g/kg body weight per day for 8 weeks. The results showed that perilla seed oil significantly reduced triglyceride levels by 38.00% and 41.88% and total cholesterol levels by 17.16% and 15.91% in the high-fat diet and normal diet groups, respectively ( < 0.05). However, perilla seed oil had no significant effect on HDL and LDL levels. Additionally, perilla seed oil supplementation significantly reduced malondialdehyde (MDA) levels, a biomarker of oxidative stress, by 68.18% in the high-fat diet group and 29.72% in the normal diet group. Regarding its anti-inflammatory effects, perilla seed oil reduced interleukin-6 (IL-6) levels by 15.21% and 64.27% in the high-fat diet and normal diet groups, respectively ( < 0.05). These findings suggest that perilla seed oil has the potential to reduce the risk of metabolic syndrome.

摘要

高脂饮食是导致高脂血症的关键因素。紫苏籽油作为一种植物性ω-3脂肪酸来源，有可能降低这种风险。然而，其效果尚未完全明确。本研究旨在评估紫苏籽油对通过高脂饮食诱导的高脂血症大鼠血脂水平、氧化应激和炎症的影响。雄性Wistar大鼠每天按0.67 g/kg体重的剂量给予紫苏籽油，持续8周。结果表明，紫苏籽油使高脂饮食组和正常饮食组的甘油三酯水平分别显著降低了38.00%和41.88%，总胆固醇水平分别显著降低了17.16%和15.91%（P<0.05）。然而，紫苏籽油对高密度脂蛋白（HDL）和低密度脂蛋白（LDL）水平没有显著影响。此外，补充紫苏籽油显著降低了氧化应激生物标志物丙二醛（MDA）的水平，高脂饮食组降低了68.18%，正常饮食组降低了29.72%。在抗炎作用方面，紫苏籽油使高脂饮食组和正常饮食组的白细胞介素-6（IL-6）水平分别降低了15.21%和64.27%（P<0.05）。这些发现表明紫苏籽油有可能降低代谢综合征的风险。