Department of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, USA.
Departments of Neurology, Pediatrics, and Pathology, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Curr Opin Neurobiol. 2017 Dec;47:156-161. doi: 10.1016/j.conb.2017.10.009. Epub 2017 Nov 6.
Gliomas are the most common primary brain tumor and high-grade gliomas the leading cause of brain tumor-related death in both children and adults. An appreciation for the crucial role of the nervous system in the tumor microenvironment is emerging for cancers in general, and the neural regulation of glioma progression has come into sharp focus. Here, we review what is known about the influence of active neurons on glioma pathobiology.
神经胶质细胞瘤是最常见的原发性脑肿瘤，高级别神经胶质细胞瘤是儿童和成人脑肿瘤相关死亡的主要原因。人们越来越认识到神经系统在肿瘤微环境中的关键作用，神经对神经胶质瘤进展的调控也成为研究的焦点。在这里，我们综述了活跃神经元对神经胶质瘤病理生物学的影响。
