Grayston J T, Diwan V K, Cooney M, Wang S P
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
Arch Intern Med. 1989 Jan;149(1):169-73.
Serum specimens from 198 patients with pneumonia hospitalized in Seattle between October 1980 and April 1981 were retrospectively tested for antibody against a recently described Chlamydia organism called TWAR. They had been previously tested for antibody for some viruses and Mycoplasma. Twenty (10%) had serologic evidence of recent TWAR infection. The hospital records of the patients with acute TWAR antibody and an equal number of matched controls were examined for clinical characteristics, laboratory tests, treatment, and course during the hospital stay. It was not possible clinically or roentgenographically to distinguish pneumonia associated with TWAR antibody from pneumonia in the controls. Nine of 20 patients with TWAR antibody acquired pneumonia during their hospital stay. The mode of transmission in the hospital was not determined. All the patients with hospital-acquired pneumonia had been intubated, and all had had some surgical procedure. Ten of 20 control patients had onset of their pneumonia in the hospital. Fifteen (11%) of 142 of the patients with pneumonia had evidence of influenza A virus infection. The clinical characteristics of their pneumonias were similar to those of the patients with acute TWAR antibody.
对1980年10月至1981年4月间在西雅图住院的198例肺炎患者的血清标本进行回顾性检测，以检测其针对一种最近描述的衣原体生物——TWAR的抗体。这些患者此前已检测过一些病毒和支原体的抗体。20例（10%）有近期TWAR感染的血清学证据。对急性TWAR抗体阳性患者和数量相等的匹配对照的医院记录进行检查，以了解其临床特征、实验室检查、治疗及住院期间的病程。在临床或影像学上无法将与TWAR抗体相关的肺炎与对照组的肺炎区分开来。20例TWAR抗体阳性患者中有9例在住院期间患上肺炎。医院内的传播方式未确定。所有医院获得性肺炎患者均已插管，且均接受过某种外科手术。20例对照患者中有10例在医院内患肺炎。142例肺炎患者中有15例（11%）有甲型流感病毒感染的证据。他们肺炎的临床特征与急性TWAR抗体阳性患者相似。
