Department of Anatomy and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
FEBS J. 2018 Feb;285(4):654-664. doi: 10.1111/febs.14325. Epub 2017 Nov 24.
Metastasis is responsible for the majority of death in cancer patients. Of the different steps in the metastasis cascade, the postdissemination phase is perhaps one of the least understood. Many factors, both from the disseminated tumor cells and the microenvironment, impact the success of the metastatic outgrowth. In this article, we discuss the interactions between colonizing cancer cells and immune cells in the period between vascular arrest in a secondary organ and metastatic outgrowth. We address the ambiguity in the findings of current research regarding the role of immune cells in regulating the metastatic microenvironment, and their hand in determining cancer cell fate.
转移是癌症患者死亡的主要原因。在转移级联的不同步骤中，播散后阶段也许是了解最少的阶段之一。许多因素，包括来自播散的肿瘤细胞和微环境，都会影响转移生长的成功。在本文中，我们讨论了在次级器官血管阻塞与转移生长之间的时期，定植癌细胞与免疫细胞之间的相互作用。我们讨论了当前研究中关于免疫细胞在调节转移微环境中的作用以及它们在决定癌细胞命运方面的作用的研究结果中的模糊性。
