Owicki J C, McConnell H M
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4750-4. doi: 10.1073/pnas.76.10.4750.
A model for protein-lipid interactions in bilayer membranes where the proteins are very dilute is extended to higher protein concentration, where appreciable lipid-mediated protein-protein interactions occur. It is found that proteins may change the lipid phase transition temperature and that they weaken the phase transition. There exists a critical protein concentration above which the sharp lipid phase transition is abolished. The model also qualitatively reproduces several experimental observations on the physical behavior of bilayers formed from mixtures of cholesterol and phosphatidylcholines.
一种用于双层膜中蛋白质 - 脂质相互作用的模型,最初适用于蛋白质非常稀的情况,现扩展到蛋白质浓度更高的情况,此时会发生明显的脂质介导的蛋白质 - 蛋白质相互作用。研究发现,蛋白质可能会改变脂质的相变温度,并减弱相变。存在一个临界蛋白质浓度,超过该浓度后,尖锐的脂质相变就会消失。该模型还定性地重现了关于由胆固醇和磷脂酰胆碱混合物形成的双层膜物理行为的若干实验观察结果。