秘鲁利马一家国立医院收治的社区获得性肺炎婴幼儿中非典型细菌病原体、病毒及合并感染的分子病因学特征
Molecular etiological profile of atypical bacterial pathogens, viruses and coinfections among infants and children with community acquired pneumonia admitted to a national hospital in Lima, Peru.
作者信息
Del Valle-Mendoza Juana, Silva-Caso Wilmer, Cornejo-Tapia Angela, Orellana-Peralta Fiorella, Verne Eduardo, Ugarte Claudia, Aguilar-Luis Miguel Angel, De Lama-Odría María Del Carmen, Nazario-Fuertes Ronald, Esquivel-Vizcarra Mónica, Casabona-Ore Verónica, Weilg Pablo, Del Valle Luis J
机构信息
School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cdra. 2. Cedros de Villa, Chorrillos, Lima, Peru.
Instituto de Investigación Nutricional, Av. La Molina 1885, Lima 12, Peru.
出版信息
BMC Res Notes. 2017 Dec 6;10(1):688. doi: 10.1186/s13104-017-3000-3.
OBJECTIVE
The main objective of this study was to detect the presence of 14 respiratory viruses and atypical bacteria (Mycoplasma pneumoniae, Chlamydia pneumoniae), via polymerase chain reaction in patients under 18 years old hospitalized due to community-acquired pneumonia (CAP) from Lima, Peru.
RESULTS
Atypical pathogens were detected in 40% (58/146); viral etiologies in 36% (52/146) and coinfections in 19% (27/146). The most common etiological agent was M. pneumoniae (n = 47), followed by C. pneumoniae (n = 11). The most frequent respiratory viruses detected were: respiratory syncytial virus A (n = 35), influenza virus C (n = 21) and parainfluenza virus (n = 10). Viral-bacterial and bacterium-bacterium coinfections were found in 27 cases. In our study population, atypical bacteria (40%) were detected as frequently as respiratory viruses (36%). The presence of M. pneumoniae and C. pneumoniae should not be underestimated as they can be commonly isolated in Peruvian children with CAP.
目的
本研究的主要目的是通过聚合酶链反应检测秘鲁利马因社区获得性肺炎（CAP）住院的18岁以下患者中14种呼吸道病毒和非典型细菌（肺炎支原体、肺炎衣原体）的存在情况。
结果
40%（58/146）的患者检测到非典型病原体；36%（52/146）为病毒病因，19%（27/146）为混合感染。最常见的病原体是肺炎支原体（n = 47），其次是肺炎衣原体（n = 11）。检测到的最常见呼吸道病毒为：呼吸道合胞病毒A（n = 35）、C型流感病毒（n = 21）和副流感病毒（n = 10）。发现27例病毒-细菌和细菌-细菌混合感染。在我们的研究人群中，非典型细菌（40%）的检出率与呼吸道病毒（36%）一样高。肺炎支原体和肺炎衣原体的存在不应被低估，因为它们在秘鲁患CAP的儿童中很常见。
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