Deliencourt-Godefroy Géraldine, Legoedec Jocelyne, Bourdens Marion, Juin Noémie, Nguyen Linh-Trang, Branchet Marie-Christine, Boisnic Sylvie, Keophiphath Mayoura
TFChem (Sirona Biochem Corp), Val-de-Reuil, France.
DIVA Expertise, Toulouse, France.
J Cosmet Dermatol. 2025 Feb;24(2):e16679. doi: 10.1111/jocd.16679. Epub 2024 Nov 17.
Anti-freeze Glycoproteins (AFGPs) were described to preserve biological materials and protect them from different stresses.
The effects of a synthetic anti-freeze glycoprotein-based compound, TFC-1326, on human skin quality and its biological actions were studied.
The effects of various concentrations of TFC-1326 on the biology of human preadipocytes, differentiated in the proinflammatory microenvironment, and on human fibroblasts grown in coculture with human mature adipocytes or monocultured in stress conditions were investigated in, in vitro studies. Additionally, the efficacy of a 1% TFC-1326 topical cream was evaluated in a clinical investigation on the skin biology and appearance of 20 women aged between 40 and 65 years throughout 84 days of application.
The in vitro studies revealed that TFC-1326 mitigated the deleterious effects of a proinflammatory cytokine cocktail produced by human macrophages, by restoring preadipocyte adipogenic capacity and by reducing their fibroinflammatory state. TFC-1326 also stimulated the proliferative capacity of dermal fibroblasts co-cultured with mature adipocytes as well as their production of hyaluronic acid and procollagen type I, while decreasing IL6 secretion and increasing fibroblast viability. Furthermore, daily 1% TFC-1326 topical cream application, measurably improved skin radiance and laxity, as well as skin density. Finally, significant reductions of the volume and depth of the crow's feet wrinkles were also observed.
The compound TFC-1326 significantly improved the physiological appearance and cellular functions of aging skin.
抗冻糖蛋白（AFGPs）被描述为可保存生物材料并保护它们免受不同应激。
研究一种基于合成抗冻糖蛋白的化合物TFC - 1326对人类皮肤质量及其生物学作用的影响。
在体外研究中，研究了不同浓度的TFC - 1326对在促炎微环境中分化的人前脂肪细胞生物学的影响，以及对与人类成熟脂肪细胞共培养或在应激条件下单培养的人成纤维细胞的影响。此外，在一项临床研究中，对20名年龄在40至65岁之间的女性，在84天的应用过程中，评估了1% TFC - 1326外用乳膏对皮肤生物学和外观的功效。
体外研究表明，TFC - 1326通过恢复前脂肪细胞的成脂能力并降低其纤维炎症状态，减轻了人类巨噬细胞产生的促炎细胞因子混合物的有害影响。TFC - 1326还刺激了与成熟脂肪细胞共培养的真皮成纤维细胞的增殖能力，以及它们的透明质酸和I型原胶原的产生，同时减少IL6分泌并提高成纤维细胞活力。此外，每天涂抹1% TFC - 1326外用乳膏，可显著改善皮肤光泽、松弛度以及皮肤密度。最后，还观察到鱼尾纹的体积和深度显著减小。
化合物TFC - 1326显著改善了衰老皮肤的生理外观和细胞功能。
