Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain.
Andalusian Institute of Earth Sciences, CSIC-University of Granada, Avda. de Las Palmeras 4, 18100, Armilla (Granada), Spain.
Chem Rec. 2018 Jul;18(7-8):891-899. doi: 10.1002/tcr.201700061. Epub 2018 Jan 5.
On/into/through the skin drug delivery represents an attractive alternative for the oral route, providing local and/or systemic drug delivery. Due to its complex and well-organised structure, most of the drugs show difficulties to penetrate the human skin. Therefore, enormous efforts have been invested to develop intelligent drug delivery systems overcoming the skin barrier with particular emphasis on increasing therapeutic activity and minimizing undesirable side-effects. Most of these strategies require the use of singular materials with new properties. In particular, and on the basis of their inherent properties, including biocompatibility, biodegradability and relative low-cost, inorganic nanoparticles are ideal candidates for the development of skin drug delivery systems. This review provides an updated and comprehensive overview of the state of the art in the trends towards skin drug delivery with a particular focus in the attractive alternative offered by inorganic-based nanosystems.
经皮给药是口服给药的一种有吸引力的替代途径，可提供局部和/或全身药物递送。由于其复杂而有序的结构，大多数药物在穿透人体皮肤方面都存在困难。因此，人们投入了大量的努力来开发智能药物递送系统，以克服皮肤屏障，特别强调提高治疗活性和最小化不良副作用。这些策略中的大多数都需要使用具有新特性的单一材料。特别是，基于其固有特性，包括生物相容性、可生物降解性和相对低成本，无机纳米粒子是开发皮肤药物递送系统的理想候选材料。本文综述了皮肤药物递送技术的最新进展和全面概述，特别关注基于无机纳米系统提供的有吸引力的替代途径。
