School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310028, China.
Sensors (Basel). 2018 Jan 7;18(1):148. doi: 10.3390/s18010148.
With the extensive applications of biomagnetic signals derived from active biological tissue in both clinical diagnoses and human-computer-interaction, there is an increasing need for approachable weak biomagnetic sensing technology. The inherent merits of giant magnetoresistance (GMR) and its high integration with multiple technologies makes it possible to detect weak biomagnetic signals with micron-sized, non-cooled and low-cost sensors, considering that the magnetic field intensity attenuates rapidly with distance. This paper focuses on the state-of-art in integrated GMR technology for approachable biomagnetic sensing from the perspective of discipline fusion between them. The progress in integrated GMR to overcome the challenges in weak biomagnetic signal detection towards high resolution portable applications is addressed. The various strategies for 1/ noise reduction and sensitivity enhancement in integrated GMR technology for sub-pT biomagnetic signal recording are discussed. In this paper, we review the developments of integrated GMR technology for in vivo/vitro biomagnetic source imaging and demonstrate how integrated GMR can be utilized for biomagnetic field detection. Since the field sensitivity of integrated GMR technology is being pushed to fT/Hz with the focused efforts, it is believed that the potential of integrated GMR technology will make it preferred choice in weak biomagnetic signal detection in the future.
随着生物活性组织的生物磁信号在临床诊断和人机交互中的广泛应用,人们对易于使用的弱生物磁传感技术的需求日益增加。巨磁电阻(GMR)的固有优势及其与多种技术的高度集成使得可以使用微米级、非冷却和低成本的传感器来检测弱生物磁信号,因为磁场强度随距离迅速衰减。本文从学科融合的角度,重点介绍了用于易于使用的生物磁传感的集成 GMR 技术的最新进展。讨论了克服弱生物磁信号检测中面临的挑战以实现高分辨率便携式应用的集成 GMR 技术的进展。讨论了用于亚皮特斯拉生物磁信号记录的集成 GMR 技术中降低 1/噪声和提高灵敏度的各种策略。本文回顾了用于体内/体外生物磁源成像的集成 GMR 技术的发展,并展示了如何利用集成 GMR 进行生物磁场检测。由于集中精力提高了集成 GMR 技术的场灵敏度,因此可以相信,集成 GMR 技术的潜力将使其成为未来弱生物磁信号检测的首选。