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芝麻酚在亚硒酸盐诱导的实验性白内障模型中的保护作用。

The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model.

作者信息

Turgut Burak, Ergen İrfan, İlhan Nevin

机构信息

Yüksek İhtisas University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Ophthalmology, Ankara, Turkey.

出版信息

Turk J Ophthalmol. 2017 Dec;47(6):309-314. doi: 10.4274/tjo.42385. Epub 2017 Dec 27.

DOI:10.4274/tjo.42385
PMID:29326846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5758764/
Abstract

OBJECTIVES

To investigate the potential protective effects of sesamol in an experimental cataract model.

MATERIALS AND METHODS

Twenty-one Spraque Dawley rat pups were randomly assigned into three groups, seven rats in each. All the rats except for those in the control group were injected subcutaneously with a single dose of sodium selenite on postpartum day 9. On days 10-14, rats in the sham group were intraperitoneally administered 50 mg/kg/day saline solution, while rats in the sesamol group were given 50 mg/kg/day sesamol by the same route. Following cataract grading, the lenses and capsules were extracted and the mean levels of reduced glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) in lens supernatants were biochemically analyzed.

RESULTS

The control group did not show any development of cataract. It was found that the mean cataract grade in the sesamol group was significantly lower than that of the sham group (p<0.05). The mean GSH level and TAS in the sesamol group were significantly higher than those of the sham group while the mean TOS and MDA level in the sesamol group were significantly lower than those of the sham group (p<0.05).

CONCLUSION

Our study shows that sesamol reduces TOS and MDA level and increases TAS and GSH level in the lens and inhibits cataract formation.

摘要

目的

研究芝麻酚在实验性白内障模型中的潜在保护作用。

材料与方法

将21只斯普拉格-道利幼鼠随机分为三组，每组7只。除对照组外，所有大鼠在出生后第9天皮下注射单剂量亚硒酸钠。在第10 - 14天，假手术组大鼠腹腔注射50 mg/kg/天的生理盐水，而芝麻酚组大鼠通过相同途径给予50 mg/kg/天的芝麻酚。白内障分级后，取出晶状体和晶状体囊，对晶状体上清液中还原型谷胱甘肽（GSH）、丙二醛（MDA）、总抗氧化状态（TAS）和总氧化状态（TOS）的平均水平进行生化分析。

结果

对照组未出现任何白内障发展情况。发现芝麻酚组的平均白内障分级显著低于假手术组（p<0.05）。芝麻酚组的平均GSH水平和TAS显著高于假手术组，而芝麻酚组的平均TOS和MDA水平显著低于假手术组（p<0.05）。

结论

我们的研究表明，芝麻酚可降低晶状体中的TOS和MDA水平，提高TAS和GSH水平，并抑制白内障形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/8e196ed97057/TJO-47-309-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/3ec3369f44bc/TJO-47-309-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/1f2ffbea2a6e/TJO-47-309-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/7b24b084275d/TJO-47-309-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/6093c455fc52/TJO-47-309-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/c7fb41f37c4d/TJO-47-309-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/8e196ed97057/TJO-47-309-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/3ec3369f44bc/TJO-47-309-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/1f2ffbea2a6e/TJO-47-309-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/7b24b084275d/TJO-47-309-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/6093c455fc52/TJO-47-309-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/c7fb41f37c4d/TJO-47-309-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24ed/5758764/8e196ed97057/TJO-47-309-g6.jpg

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Eur J Pharmacol. 2015 Jan 15;747:132-40. doi: 10.1016/j.ejphar.2014.11.014. Epub 2014 Nov 20.
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Antioxidant potential of sesamol and its role on radiation-induced DNA damage in whole-body irradiated Swiss albino mice.芝麻酚的抗氧化潜力及其对全身放射照射的瑞士白化病小鼠 DNA 损伤的作用。
Environ Toxicol Pharmacol. 2009 Sep;28(2):192-7. doi: 10.1016/j.etap.2009.04.003. Epub 2009 Apr 11.
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Photoprotective effect of sesamol on UVB-radiation induced oxidative stress in human blood lymphocytes in vitro.
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Environ Toxicol Pharmacol. 2005 Jul;20(1):1-5. doi: 10.1016/j.etap.2004.09.009. Epub 2004 Nov 24.
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The interplay of glutathione-related processes in antioxidant defense.谷胱甘肽相关过程在抗氧化防御中的相互作用。
Environ Toxicol Pharmacol. 2001 Sep;10(4):141-52. doi: 10.1016/s1382-6689(01)00077-1.
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Ophthalmic Res. 2010;44(3):155-65. doi: 10.1159/000316481. Epub 2010 Sep 9.
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