From the Department of Ophthalmology (Panthier, Burgos, Rouger, Saad, Gatinel), Rothschild Foundation, and the Center of Expertise and Research in Optics for Clinicians (Saad, Gatinel), Paris, France; the Department of Ophthalmology (Saad), American University of Beirut, Beirut, Lebanon.
From the Department of Ophthalmology (Panthier, Burgos, Rouger, Saad, Gatinel), Rothschild Foundation, and the Center of Expertise and Research in Optics for Clinicians (Saad, Gatinel), Paris, France; the Department of Ophthalmology (Saad), American University of Beirut, Beirut, Lebanon.
J Cataract Refract Surg. 2017 Dec;43(12):1575-1581. doi: 10.1016/j.jcrs.2017.09.028.
To assess a new objective cataract grading method based on lens densitometry on swept-source optical coherence tomography (SS-OCT) scans provided by the IOLMaster 700.
Rothschild Foundation, Paris, France.
Prospective case series.
All patients consulting for cataract evaluation who provided their consent to participate in the study were included. A history of eye surgery, corneal or retinal disorders, and ocular dryness were exclusion criteria. The average lens densitometry was measured with SS-OCT scans using ImageJ software. The ocular scatter index (OSI) measured with a double-pass aberrometer (Optical Quality Analysis System), the Pentacam nucleus staging (hereafter referred to as nuclear staging) score, and mean nuclear staging were also measured and compared with the mean lens densitometry.
One hundred ten eyes (51 with cataract and 59 controls) were included. The average lens densitometry measurements were repeatable (P = .99, analysis of variance). The repeatability limit was 2.50 pixel units. The average lens density was correlated with the OSI (r = 0.52, P < .01), nuclear staging score (r = 0.75, P < .01), and mean nuclear staging (r = 0.41, P < .01). An average lens density greater than 82.9 pixel units was the cutoff threshold for cataract, with a sensitivity of 73.9% and a specificity of 91.2%.
The average lens density measured by SS-OCT was a repeatable and reliable objective cataract grading method. It was correlated with OSI measurement. If the average lens density was greater than 82.9 pixel units and the patient reported visual impairment, cataract surgery might be discussed.
评估一种基于扫频源光相干断层扫描（SS-OCT）仪 IOLMaster 700 所提供的晶状体密度测量的新型白内障客观分级方法。
法国巴黎 Rothschild 基金会。
前瞻性病例系列研究。
所有同意参与研究的因白内障就诊并提供知情同意书的患者均被纳入。眼部手术史、角膜或视网膜疾病以及眼干燥症为排除标准。使用 ImageJ 软件对 SS-OCT 扫描进行平均晶状体密度测量。还测量了双光折射像差仪（光学质量分析系统）测量的眼散射指数（OSI）、Pentacam 核分期（以下简称核分期）评分和平均核分期，并与平均晶状体密度进行比较。
共纳入 110 只眼（51 只白内障眼和 59 只对照眼）。平均晶状体密度测量结果具有可重复性（P =.99，方差分析）。重复性限为 2.50 像素单位。平均晶状体密度与 OSI（r = 0.52，P <.01）、核分期评分（r = 0.75，P <.01）和平均核分期（r = 0.41，P <.01）相关。平均晶状体密度大于 82.9 像素单位是白内障的截断阈值，其灵敏度为 73.9%，特异性为 91.2%。
SS-OCT 测量的平均晶状体密度是一种可重复且可靠的白内障客观分级方法。它与 OSI 测量相关。如果平均晶状体密度大于 82.9 像素单位且患者报告视力受损，可能会讨论白内障手术。
