日本多发性硬化症简短国际认知评估的验证
Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan.
作者信息
Niino Masaaki, Fukazawa Toshiyuki, Kira Jun-Ichi, Okuno Tatsusada, Mori Masahiro, Sanjo Nobuo, Ohashi Takashi, Fukaura Hikoaki, Fujimori Juichi, Shimizu Yuko, Mifune Nobuhiro, Miyazaki Yusei, Takahashi Eri, Kikuchi Seiji, Langdon Dawn, Hb Benedict Ralph, Matsui Makoto
机构信息
Department of Clinical Research, Hokkaido Medical Center, Japan.
Sapporo Neurology Hospital, Japan.
出版信息
Mult Scler J Exp Transl Clin. 2017 Dec 26;3(4):2055217317748972. doi: 10.1177/2055217317748972. eCollection 2017 Oct-Dec.
BACKGROUND
The Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).
OBJECTIVES
We aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.
METHODS
The Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.
RESULTS
The mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests ( < 0.0001). Cohen's values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: = 0.93; CVLT2: = 0.82; and BVMTR: = 0.77 ( < 0.0001).
CONCLUSIONS
This study provides results that support the reliability and validity of the BICAMS in Japan.
背景
简短国际多发性硬化症认知评估量表（BICAMS）是一种用于测量多发性硬化症（MS）认知功能的实用成套测试工具。
目的
我们旨在对MS患者和健康对照者验证BICAMS的日语版本。
方法
对156例MS患者和126名健康对照者（HCs）进行了符号数字模式测试（SDMT）、加利福尼亚言语学习测试第二版（CVLT2）和修订的简短视觉空间记忆测试（BVMTR）。对27例MS患者和30名HCs的一个亚组再次进行了BICAMS测试。
结果
MS组和HC组的平均（±标准差）原始分数如下：SDMT：MS组为47.9±14.0，HC组为61.0±9.5；CVLT2：MS组为48.6±12.6，HC组为55.7±10.5；BVMTR：MS组为23.5±8.4，HC组为28.3±5.4，并且在所有测试中两组之间均发现有显著差异（<0.0001）。SDMT、CVLT2和BVMTR的科恩效应值分别为1.07、0.60和0.67。每项测试的重测信度系数如下：SDMT：=0.93；CVLT2：=0.82；BVMTR：=0.77（<0.0001）。
结论
本研究提供的结果支持BICAMS在日本的可靠性和有效性。
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