Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel.
Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel
J R Soc Interface. 2018 Jan;15(138). doi: 10.1098/rsif.2017.0380.
Muscular diseases such as muscular dystrophies and muscle injuries constitute a large group of ailments that manifest as muscle weakness, atrophy or fibrosis. Although cell therapy is a promising treatment option, the delivery and retention of cells in the muscle is difficult and prevents sustained regeneration needed for adequate functional improvements. Various types of biomaterials with different physical and chemical properties have been developed to improve the delivery of cells and/or growth factors for treating muscle injuries. Hydrogels are a family of materials with distinct advantages for use as cell delivery systems in muscle injuries and ailments, including their mild processing conditions, their similarities to natural tissue extracellular matrix, and their ability to be delivered with less invasive approaches. Moreover, hydrogels can be made to completely degrade in the body, leaving behind their biological payload in a process that can enhance the therapeutic process. For these reasons, hydrogels have shown great potential as cell delivery matrices. This paper reviews a few of the hydrogel systems currently being applied together with cell therapy and/or growth factor delivery to promote the therapeutic repair of muscle injuries and muscle wasting diseases such as muscular dystrophies.
肌肉疾病，如肌肉营养不良和肌肉损伤，构成了一大类以肌肉无力、萎缩或纤维化为表现的疾病。尽管细胞疗法是一种很有前途的治疗选择，但细胞在肌肉中的传递和保留很困难，这阻碍了充分的功能改善所需的持续再生。已经开发出各种具有不同物理和化学性质的生物材料，以改善细胞和/或生长因子的传递，用于治疗肌肉损伤。水凝胶是一类材料，具有作为肌肉损伤和疾病中细胞传递系统的独特优势，包括其温和的处理条件、与天然组织细胞外基质的相似性，以及可以通过微创方法传递的能力。此外，水凝胶可以在体内完全降解，在这个过程中，它们的生物有效载荷可以增强治疗过程。由于这些原因，水凝胶作为细胞传递基质显示出巨大的潜力。本文综述了目前应用于细胞治疗和/或生长因子传递的几种水凝胶系统，以促进肌肉损伤和肌肉消耗性疾病（如肌肉营养不良）的治疗修复。
