线粒体融合蛋白的“进”与“出”。
The INs and OUTs of mitofusins.
机构信息
Department of Biology, University of Padua, Padua, Italy.
Department of Biology, University of Padua, Padua, Italy
出版信息
J Cell Biol. 2018 Feb 5;217(2):439-440. doi: 10.1083/jcb.201801042. Epub 2018 Jan 18.
Abstract
Mitofusins are outer membrane proteins essential for mitochondrial fusion. Their accepted topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al. (2018. https://doi.org/10.1083/jcb.201611194) demonstrate instead that their C termini reside in the intermembrane space. These findings call for a revision of the current models of mitochondrial fusion.
摘要
线粒体融合蛋白（Mitofusins）是线粒体融合所必需的外膜蛋白。公认的拓扑结构假设它们的 N 端和 C 端都朝向细胞质。在本期杂志中，Mattie 等人（2018. https://doi.org/10.1083/jcb.201611194）证明它们的 C 端位于膜间隙中。这些发现要求对当前的线粒体融合模型进行修订。
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