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线粒体融合蛋白的“进”与“出”。

The INs and OUTs of mitofusins.

机构信息

Department of Biology, University of Padua, Padua, Italy.

Department of Biology, University of Padua, Padua, Italy

出版信息

J Cell Biol. 2018 Feb 5;217(2):439-440. doi: 10.1083/jcb.201801042. Epub 2018 Jan 18.

DOI:10.1083/jcb.201801042
PMID:29348146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5800822/
Abstract

Mitofusins are outer membrane proteins essential for mitochondrial fusion. Their accepted topology posits that both N and C termini face the cytoplasm. In this issue, Mattie et al. (2018. https://doi.org/10.1083/jcb.201611194) demonstrate instead that their C termini reside in the intermembrane space. These findings call for a revision of the current models of mitochondrial fusion.

摘要

线粒体融合蛋白（Mitofusins）是线粒体融合所必需的外膜蛋白。公认的拓扑结构假设它们的 N 端和 C 端都朝向细胞质。在本期杂志中，Mattie 等人（2018. https://doi.org/10.1083/jcb.201611194）证明它们的 C 端位于膜间隙中。这些发现要求对当前的线粒体融合模型进行修订。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabb/5800822/e964879dde50/JCB_201801042_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabb/5800822/e964879dde50/JCB_201801042_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabb/5800822/e964879dde50/JCB_201801042_Fig1.jpg

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2
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Cell Rep. 2016 Dec 13;17(11):3024-3034. doi: 10.1016/j.celrep.2016.11.049.
3
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Free Radic Biol Med. 2024 Jan;210:183-194. doi: 10.1016/j.freeradbiomed.2023.11.008. Epub 2023 Nov 17.
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Basic Res Cardiol. 2023 Nov 13;118(1):49. doi: 10.1007/s00395-023-01019-9.
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Mitochondrial dynamics involves molecular and mechanical events in motility, fusion and fission.线粒体动力学涉及运动、融合和裂变中的分子及机械事件。
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