Stern A S, Lewis R V, Kimura S, Rossier J, Gerber L D, Brink L, Stein S, Udenfriend S
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6680-3. doi: 10.1073/pnas.76.12.6680.
Bovine adrenal chromaffin granules have been shown to contain, in addition to Met-enkephalin and Leu-enkephalin, at least three small peptides with opiate receptor activity. One of these adrenal peptides has been purified to homogeneity and its sequence was shown to be Met-enkephalin-[Arg6,Phe&]. This heptapeptide was also found in beef striatal extracts in amounts comparable to those of Leu-enkephalin.
已证明牛肾上腺嗜铬颗粒除含有甲硫氨酸脑啡肽和亮氨酸脑啡肽外,还含有至少三种具有阿片受体活性的小肽。其中一种肾上腺肽已纯化至同质,其序列显示为甲硫氨酸脑啡肽-[精氨酸6,苯丙氨酸8]。这种七肽在牛肉纹状体提取物中的含量与亮氨酸脑啡肽相当。