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1
Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.从牛肾上腺髓质颗粒和纹状体中分离阿片样七肽甲硫氨酸脑啡肽[Arg6，Phe7]。
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6680-3. doi: 10.1073/pnas.76.12.6680.
2
Met-enkephalin [Arg6, Phe7] immunoreactivity in bovine caudate and bovine adrenal medulla.牛尾状核和牛肾上腺髓质中脑啡肽[精氨酸6，苯丙氨酸7]免疫反应性
J Neurochem. 1982 Jul;39(1):149-54. doi: 10.1111/j.1471-4159.1982.tb04713.x.
3
Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist.甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7，在大鼠、牛和人的大脑中大量存在，是一种阿片类激动剂。
Nature. 1980 Nov 6;288(5786):88-90. doi: 10.1038/288088a0.
4
Identification of the octapeptide [Met]enkephalin -Arg6-Gly7-Leu8 in extracts of bovine adrenal medulla.牛肾上腺髓质提取物中八肽[甲硫氨酸]脑啡肽-精氨酸6-甘氨酸7-亮氨酸8的鉴定。
Biochem Biophys Res Commun. 1981 Nov 30;103(2):698-705. doi: 10.1016/0006-291x(81)90506-4.
5
An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.肾上腺髓质中一种约50,000道尔顿的蛋白质：[甲硫氨酸]-脑啡肽和[亮氨酸]-脑啡肽的共同前体。
Science. 1980 Jun 27;208(4451):1459-61. doi: 10.1126/science.7384787.
6
A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.一种高效的3200道尔顿肾上腺阿片肽，其包含甲硫氨酸脑啡肽和亮氨酸脑啡肽序列。
Proc Natl Acad Sci U S A. 1981 May;78(5):3265-8. doi: 10.1073/pnas.78.5.3265.
7
Probable precursors of [Leu]enkephalin and [Met]enkephalin in adrenal medulla: peptides of 3-5 kilodaltons.肾上腺髓质中[亮氨酸]脑啡肽和[甲硫氨酸]脑啡肽可能的前体：3至5千道尔顿的肽类。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1681-5. doi: 10.1073/pnas.77.3.1681.
8
Enkephalin biosynthetic pathway: a 5300-dalton adrenal polypeptide that terminates at its COOH end with the sequence [Met]enkephalin-Arg-Gly-Leu-COOH.脑啡肽生物合成途径：一种5300道尔顿的肾上腺多肽，其COOH末端以序列[甲硫氨酸]脑啡肽-精氨酸-甘氨酸-亮氨酸-COOH终止。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1313-5. doi: 10.1073/pnas.79.4.1313.
9
Purification of the N-terminal fragment of proenkephalin from bovine adrenal medulla.从牛肾上腺髓质中纯化脑啡肽原N端片段。
Life Sci. 1983;33 Suppl 1:45-7. doi: 10.1016/0024-3205(83)90440-x.
10
Two adrenal opioid polypeptides: proposed intermediates in the processing of proenkephalin.两种肾上腺阿片样多肽：脑啡肽原加工过程中的假定中间体。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1962-6. doi: 10.1073/pnas.78.3.1962.

引用本文的文献

1
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions.五十年来阿片肽研究：现有知识与未解问题。
Mol Pharmacol. 2020 Aug;98(2):96-108. doi: 10.1124/mol.120.119388. Epub 2020 Jun 2.
2
Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets.羧肽酶E与新型神经肽作为潜在治疗靶点的鉴定。
Adv Pharmacol. 2018;82:85-102. doi: 10.1016/bs.apha.2017.09.001. Epub 2017 Nov 8.
3
Autonomic control of adrenal function.肾上腺功能的自主控制。
J Anat. 1993 Oct;183 ( Pt 2)(Pt 2):291-307.
4
Purification of opioid peptides from molluscan ganglia.从软体动物神经节中纯化阿片肽。
Cell Mol Neurobiol. 1982 Dec;2(4):347-52. doi: 10.1007/BF00710854.
5
FMRFamide-like immunoreactivity in the nervous system of Hydra.水螅神经系统中的FMRF酰胺样免疫反应性。
Histochemistry. 1982;73(4):499-508. doi: 10.1007/BF00493364.
6
An 18,200-dalton adrenal protein that contains four [Met]enkephalin sequences.一种18200道尔顿的肾上腺蛋白，含有四个甲硫氨酸脑啡肽序列。
Proc Natl Acad Sci U S A. 1982 May;79(9):3057-61. doi: 10.1073/pnas.79.9.3057.
7
Enkephalin biosynthetic pathway: a 5300-dalton adrenal polypeptide that terminates at its COOH end with the sequence [Met]enkephalin-Arg-Gly-Leu-COOH.脑啡肽生物合成途径：一种5300道尔顿的肾上腺多肽，其COOH末端以序列[甲硫氨酸]脑啡肽-精氨酸-甘氨酸-亮氨酸-COOH终止。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1313-5. doi: 10.1073/pnas.79.4.1313.
8
Two adrenal opioid polypeptides: proposed intermediates in the processing of proenkephalin.两种肾上腺阿片样多肽：脑啡肽原加工过程中的假定中间体。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1962-6. doi: 10.1073/pnas.78.3.1962.
9
Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands.从灌注的牛肉肾上腺中释放脑啡肽和含脑啡肽的多肽。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7473-5. doi: 10.1073/pnas.77.12.7473.
10
Studies with [35S]methionine indicate that the 22,000-dalton [Met]enkephalin-containing protein in chromaffin cells is a precursor of [Met]enkephalin.用[35S]甲硫氨酸进行的研究表明，嗜铬细胞中含22,000道尔顿[甲硫氨酸]脑啡肽的蛋白质是[甲硫氨酸]脑啡肽的前体。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6889-91. doi: 10.1073/pnas.77.11.6889.

本文引用的文献

1
A simple method for the isolation of adrenal chromaffin granules on a large scale.一种大规模分离肾上腺嗜铬颗粒的简单方法。
Biochem J. 1967 May;103(2):480-2. doi: 10.1042/bj1030480.
2
Amino acid analysis with fluorescamine at the picomole level.皮摩尔水平的荧光胺氨基酸分析。
Arch Biochem Biophys. 1973 Mar;155(1):202-12. doi: 10.1016/s0003-9861(73)80022-0.
3
Identification of two related pentapeptides from the brain with potent opiate agonist activity.从大脑中鉴定出两种具有强效阿片激动剂活性的相关五肽。
Nature. 1975 Dec 18;258(5536):577-80. doi: 10.1038/258577a0.
4
Automatic Monitoring of primary amines in preparative column effluents with fluorescamine.使用荧光胺自动监测制备柱流出物中的伯胺。
Anal Biochem. 1975 Aug;67(2):438-45. doi: 10.1016/0003-2697(75)90316-4.
5
Detection of two endorphin-like peptides in nucleus caudatus.
Neuropharmacology. 1978 Jun;17(6):433-8. doi: 10.1016/0028-3908(78)90023-0.
6
Putative enkephalin precursors in bovine adrenal medulla.牛肾上腺髓质中假定的脑啡肽前体。
Biochem Biophys Res Commun. 1979 Aug 13;89(3):822-9. doi: 10.1016/0006-291x(79)91852-7.
7
alpha-Neo-endorphin : a "big" Leu-enkephalin with potent opiate activity from porcine hypothalami.α-新内啡肽：一种来自猪下丘脑的具有强效阿片样活性的“大”亮氨酸脑啡肽。
Biochem Biophys Res Commun. 1979 Jan 15;86(1):153-60. doi: 10.1016/0006-291x(79)90394-2.
8
Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla.
Neuroscience. 1978;3(12):1169-86. doi: 10.1016/0306-4522(78)90137-9.
9
Enkephalin-like immunoreactivity in nerve terminals in sympathetic ganglia and adrenal medulla and in adrenal medullary gland cells.
Acta Physiol Scand. 1978 Aug;103(4):475-7. doi: 10.1111/j.1748-1716.1978.tb06243.x.
10
Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies.大鼠脑中含β-内啡肽的神经元与含脑啡肽的神经元是分开存在的：免疫细胞化学研究。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1591-5. doi: 10.1073/pnas.75.3.1591.

从牛肾上腺髓质颗粒和纹状体中分离阿片样七肽甲硫氨酸脑啡肽[Arg6，Phe7]。

Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.

作者信息

Stern A S, Lewis R V, Kimura S, Rossier J, Gerber L D, Brink L, Stein S, Udenfriend S

出版信息

Proc Natl Acad Sci U S A. 1979 Dec;76(12):6680-3. doi: 10.1073/pnas.76.12.6680.

DOI:10.1073/pnas.76.12.6680
PMID:293754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411932/
Abstract

Bovine adrenal chromaffin granules have been shown to contain, in addition to Met-enkephalin and Leu-enkephalin, at least three small peptides with opiate receptor activity. One of these adrenal peptides has been purified to homogeneity and its sequence was shown to be Met-enkephalin-[Arg6,Phe&]. This heptapeptide was also found in beef striatal extracts in amounts comparable to those of Leu-enkephalin.

摘要

已证明牛肾上腺嗜铬颗粒除含有甲硫氨酸脑啡肽和亮氨酸脑啡肽外，还含有至少三种具有阿片受体活性的小肽。其中一种肾上腺肽已纯化至同质，其序列显示为甲硫氨酸脑啡肽-[精氨酸6，苯丙氨酸8]。这种七肽在牛肉纹状体提取物中的含量与亮氨酸脑啡肽相当。