Ghosh Siddhartha S, He Hongliang, Wang Jing, Gehr Todd W, Ghosh Shobha
a Department of Internal Medicine , Virginia Commonwealth University Medical Center , Richmond , VA.
Tissue Barriers. 2018 Jan 2;6(1):e1425085. doi: 10.1080/21688370.2018.1425085. Epub 2018 Feb 8.
Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative properties established largely by in vitro studies. Accordingly, oral administration of curcumin beneficially modulates many diseases including diabetes, fatty-liver disease, atherosclerosis, arthritis, cancer and neurological disorders such as depression, Alzheimer's or Parkinson's disease. However, limited bioavailability and inability to detect curcumin in circulation or target tissues has hindered the validation of a causal role. We established curcumin-mediated decrease in the release of gut bacteria-derived lipopolysaccharide (LPS) into circulation by maintaining the integrity of the intestinal barrier function as the mechanism underlying the attenuation of metabolic diseases (diabetes, atherosclerosis, kidney disease) by curcumin supplementation precluding the need for curcumin absorption. In view of the causative role of circulating LPS and resulting chronic inflammation in the development of diseases listed above, this review summarizes the mechanism by which curcumin affects the several layers of the intestinal barrier and, despite negligible absorption, can beneficially modulate these diseases.
姜黄素具有抗炎、抗氧化和抗增殖特性，这些特性主要是通过体外研究确定的。因此，口服姜黄素可有益地调节多种疾病，包括糖尿病、脂肪肝疾病、动脉粥样硬化、关节炎、癌症以及神经紊乱，如抑郁症、阿尔茨海默病或帕金森病。然而，生物利用度有限以及无法在循环系统或靶组织中检测到姜黄素，阻碍了对其因果作用的验证。我们确定，姜黄素通过维持肠道屏障功能的完整性，介导肠道细菌衍生的脂多糖（LPS）释放到循环系统中的减少，这是补充姜黄素减轻代谢性疾病（糖尿病、动脉粥样硬化、肾脏疾病）的潜在机制，而无需姜黄素吸收。鉴于循环LPS及其导致的慢性炎症在上述疾病发展中的致病作用，本综述总结了姜黄素影响肠道屏障多层结构的机制，并且尽管吸收可忽略不计，但仍可有益地调节这些疾病。
