Department of Gastroenterology, Nanshan Hospital, Guangdong Medical University, Shenzhen 518052, China.
Department of Anesthesiology, Nanshan Hospital, Guangdong Medical University, Shenzhen 518052, China.
Biomed Res Int. 2017;2017:6543014. doi: 10.1155/2017/6543014. Epub 2017 Dec 24.
The aim of this study was to compare gastric residual volume (GRV) in patients given a split-dose versus a conventional single-dose of polyethylene glycol (PEG) preparation before undergoing anesthetic colonoscopy. In a prospective observational study, we assessed GRV in outpatients undergoing same-day anesthetic gastroscopy and colonoscopy between October 8 and December 30 of 2016. Outpatients were assigned to the split-dose (1 L PEG in the prior evening and 1 L PEG 2-4 h before endoscopy) or single-dose (ingestion of 2 L PEG ≥ 6 h before endoscopy) regimen randomly. Bowel cleansing quality was assessed with the Boston Bowel Preparation Scale (BBPS). The median GRV in the split-dose group (17 ml, with a range of 0-50 ml; = 65) was significantly lower than that in the single-dose group (22 ml, with a range of 0-62 ml; = 64; = 0.005), with a better bowel cleansing quality (BBPS score 8.05 ± 0.82 versus 7.64 ± 1.21; = 0.028). GRV was not associated with diabetes or the use of medications. GRV after a split-dose preparation and fasting for 2-4 hours is not larger than that after a conventional single-dose preparation and fasting for 6-8 hours. The data indicates that the split-dose bowel preparation might not increase the risk of aspiration.
本研究旨在比较接受聚乙二醇（PEG）分剂量与传统单剂量给药的患者的胃残留量（GRV）。在一项前瞻性观察研究中，我们评估了 2016 年 10 月 8 日至 12 月 30 日接受当天麻醉胃镜和结肠镜检查的门诊患者的 GRV。门诊患者随机分为分剂量组（前夜服用 1L PEG，内镜检查前 2-4 小时服用 1L PEG）或单剂量组（内镜检查前 6-8 小时服用 2L PEG）。用波士顿肠道准备量表（BBPS）评估肠道清洁质量。分剂量组的中位 GRV（17ml，范围 0-50ml； = 65）明显低于单剂量组（22ml，范围 0-62ml； = 64； = 0.005），肠道清洁质量更好（BBPS 评分 8.05 ± 0.82 比 7.64 ± 1.21； = 0.028）。GRV 与糖尿病或药物使用无关。分剂量准备和禁食 2-4 小时后的 GRV 并不大于传统单剂量准备和禁食 6-8 小时后的 GRV。数据表明，分剂量肠道准备可能不会增加吸入的风险。
