Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
Mayo Clin Proc. 2018 Mar;93(3):291-299. doi: 10.1016/j.mayocp.2017.11.018. Epub 2018 Feb 14.
To evaluate trends in the incidence of kidney stones and characteristics associated with changes in the incidence rate over 3 decades.
Adult stone formers in Olmsted County, Minnesota, from January 1, 1984, to December 31, 2012, were validated and characterized by age, sex, stone composition, and imaging modality. The incidence of kidney stones per 100,000 person-years was estimated. Characteristics associated with changes in the incidence rate over time were assessed using Poisson regression models.
There were 3224 confirmed symptomatic (stone seen), 606 suspected symptomatic (no stone seen), and 617 incidental asymptomatic kidney stone formers. The incidence of confirmed symptomatic kidney stones increased from the year 1984 to 2012 in both men (145 to 299/100,000 person-years; incidence rate ratio per 5 years, 1.14, P<.001) and women (51 to 217/100,000 person-years; incidence rate ratio per 5 years, 1.29, P<.001). Overall, the incidence of suspected symptomatic kidney stones did not change, but that of asymptomatic kidney stones increased. Utilization of computed tomography for confirmed symptomatic stones increased from 1.8% in 1984 to 77% in 2012; there was a corresponding higher increased incidence of symptomatic small stones (≤3 mm) than of larger stones (>3 mm). Confirmed symptomatic kidney stones with documented spontaneous passage also increased. The incidence of kidney stones with unknown composition increased more than that of stones with known composition.
The incidence of both symptomatic and asymptomatic kidney stones has increased dramatically. The increased utilization of computed tomography during this period may have improved stone detection and contributed to the increased kidney stone incidence.
评估肾结石发病率的趋势以及与发病率变化相关的特征,研究跨度为 30 年。
明尼苏达州奥姆斯特德县 1984 年 1 月 1 日至 2012 年 12 月 31 日期间的成年肾结石患者经验证后,按年龄、性别、结石成分和影像学方式进行特征描述。通过计算每 10 万人年的肾结石发生率来评估发病率。使用泊松回归模型评估与随时间变化的发病率变化相关的特征。
共发现 3224 例确诊的有症状肾结石(可见结石)、606 例疑似有症状肾结石(未见结石)和 617 例偶发性无症状肾结石患者。1984 年至 2012 年,男性确诊的有症状肾结石发病率(145 至 299/100,000 人年;每 5 年发病率比,1.14,P<.001)和女性(51 至 217/100,000 人年;发病率比,1.29,P<.001)均呈上升趋势。总体而言,疑似有症状肾结石的发病率没有变化,但无症状肾结石的发病率有所增加。确诊有症状肾结石中,计算机断层扫描的使用率从 1984 年的 1.8%增加到 2012 年的 77%;相应地,较小的有症状结石(≤3mm)的发病率增加幅度高于较大的结石(>3mm)。有记录显示自行排出的确诊有症状肾结石也有所增加。未知成分的肾结石发病率增加幅度超过已知成分的肾结石。
有症状和无症状肾结石的发病率都显著增加。在此期间,计算机断层扫描的广泛应用可能提高了结石的检出率,导致肾结石发病率的增加。