de Freitas Marcia Christina Dornelas, de Miranda Marina Barcelos, de Oliveira Daiane Teixeira, Vieira-Filho Sidney Augusto, Caligiorne Rachel Basques, de Figueiredo Sonia Maria
Escola de Nutricao, Universidade Federal de Ouro Preto-Campus Morro do Cruzeiro, Ouro Preto 35400-000, Minas Gerais, Brazil.
Escola de Farmacia, Universidade Federal de Ouro Preto-Campus Morro do Cruzeiro, Ouro Preto 35400-000, Minas Gerais, Brazil.
Recent Pat Endocr Metab Immune Drug Discov. 2017;11(1):3-12. doi: 10.2174/1872214812666180223120316.
The red propolis (RdProp) is a resin produced by Apis mellifera bees, which collect the reddish exudate on the surface of its botanic source, the species Dalbergia ecastophyllum, popularly known in Brazil as "rabo de bugio". Considered as the 13th type of Brazilian propolis, this resin has been gaining prominence due to its natural composition, rich in bioactive substances not found in other types of propolis.
This review aims to address the most important characteristics of RdProp, its botanical origin, the main constituents, its biological properties and the patents related to this natural product.
By means of the SciFinder, Google Patents, Patus® and Spacenet, scientific articles and patents involving the term "red propolis" were searched until August 2017.
A number of biological properties, including antimicrobial, anti-inflammatory, antiparasitic, antitumor, antioxidant, metabolic and nutraceutical activities are attributed to RdProp, demonstrating the great potential of its use in the food, pharmaceutical and cosmetics industries.
The available papers are associated to pharmacological potential of RdProp, but the molecular mechanisms or bioactive compounds responsible for each activity have not yet been fully elucidat ed. The RdProp patents currently found are directed to components for the pharmaceutical industry (EP2070543A1; WO2014186851A1; FR3006589A1; CN1775277A; CN105797149A; CN1879859A), cosmetic (JP6012138B2; JP2008247830A; JP6012138B2) and food (JP5478392B2; CN101380052A; WO2006038690A1).
红蜂胶（RdProp）是蜜蜂采集植物源——在巴西俗称“rabo de bugio”的黑黄檀（Dalbergia ecastophyllum）表面的微红渗出物而产生的一种树脂。这种树脂被视为巴西蜂胶的第13种类型，因其天然成分，富含其他类型蜂胶中未发现的生物活性物质，而日益受到关注。
本综述旨在阐述红蜂胶的最重要特征、其植物来源、主要成分、生物学特性以及与该天然产物相关的专利。
通过SciFinder、谷歌专利、Patus®和Spacenet，检索截至2017年8月涉及“红蜂胶”一词的科学文章和专利。
红蜂胶具有多种生物学特性，包括抗菌、抗炎、抗寄生虫、抗肿瘤、抗氧化、代谢和营养保健活性，显示出其在食品、制药和化妆品行业的巨大应用潜力。
现有文献与红蜂胶的药理潜力相关，但每种活性所涉及的分子机制或生物活性化合物尚未完全阐明。目前发现的红蜂胶专利涉及制药行业的成分（EP2070543A1；WO2014186851A1；FR3006589A1；CN1775277A；CN105797149A；CN1879859A）、化妆品（JP6012138B2；JP2008247830A；JP6012138B2）和食品（JP5478392B2；CN101380052A；WO2006038690A1）。
