萨尔瓦多紫檀根中的新抗氧化含硫咪唑啉生物碱——佩斯卡林。
Persicaline, A New Antioxidant Sulphur-Containing Imidazoline Alkaloid from Salvadora persica Roots.
机构信息
Pharmacognosy Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut P.O. Box 71526, Egypt.
出版信息
Molecules. 2018 Feb 23;23(2):483. doi: 10.3390/molecules23020483.
L. is a popular chewing stick commonly known as "miswak". During our ongoing research activities on the chemical constituents of roots, which is a new sulphur-containing imidazoline alkaloid 1,3-Dibenzyl-4-(1,2,3,4-tetrahydroxy-butyl)-1,3-dihydro-imidazole-2-thione, persicaline, () along with five known compounds (-) are identified. Compounds (, ) were reported for the first time from the family . The structure of the new compound was established by extensive spectroscopic data and HR-MS. The antioxidant activities of the fractions and isolates were evaluated using different in vitro methods, such as DPPH, superoxide anion and nitric oxide radicals scavenging assays. Compound () showed a promising antioxidant activity with IC 0.1, 0.08, and 0.09 µM in the three assays, respectively, comparable to ascorbic acid.
L. 是一种常见的咀嚼棒，通常被称为“miswak”。在我们正在进行的关于根化学成分的研究活动中，发现了一种新的含硫咪唑啉生物碱 1,3-二苄基-4-(1,2,3,4-四羟基丁基)-1,3-二氢咪唑-2-硫酮，即 persicaline，()，以及另外五种已知化合物(-)。化合物 (, ) 首次从该科中被报道。新化合物的结构通过广泛的光谱数据和高分辨质谱确定。采用不同的体外方法，如 DPPH、超氧阴离子和一氧化氮自由基清除测定法，评估了馏分和分离物的抗氧化活性。化合物 () 在三种测定方法中均显示出有前途的抗氧化活性，IC 0.1、0.08 和 0.09 µM，与抗坏血酸相当。
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