Department of Emergency Medicine, UCLA (University of California, Los Angeles).
RAND, Santa Monica, California.
JAMA Intern Med. 2018 Apr 1;178(4):477-484. doi: 10.1001/jamainternmed.2017.8628.
The Institute of Medicine described diagnostic error as the next frontier in patient safety and highlighted a critical need for better measurement tools.
To estimate the proportions of emergency department (ED) visits attributable to symptoms of imminent ruptured abdominal aortic aneurysm (AAA), acute myocardial infarction (AMI), stroke, aortic dissection, and subarachnoid hemorrhage (SAH) that end in discharge without diagnosis; to evaluate longitudinal trends; and to identify patient characteristics independently associated with missed diagnostic opportunities.
DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective cohort study of all Medicare claims for 2006 to 2014. The setting was hospital EDs in the United States. Participants included all fee-for-service Medicare patients admitted to the hospital during 2007 to 2014 for the conditions of interest. Hospice enrollees and patients with recent skilled nursing facility stays were excluded.
The proportion of potential diagnostic opportunities missed in the ED was estimated using the difference between observed and expected ED discharges within 45 days of the index hospital admissions as the numerator, basing expected discharges on ED use by the same patients in earlier months. The denominator was estimated as the number of recognized emergencies (index hospital admissions) plus unrecognized emergencies (excess discharges).
There were 1 561 940 patients, including 17 963 hospitalized for ruptured AAA, 304 980 for AMI, 1 181 648 for stroke, 19 675 for aortic dissection, and 37 674 for SAH. The mean (SD) age was 77.9 (10.3) years; 8.9% were younger than 65 years, and 54.1% were female. The proportions of diagnostic opportunities missed in the ED were as follows: ruptured AAA (3.4%; 95% CI, 2.9%-4.0%), AMI (2.3%; 95% CI, 2.1%-2.4%), stroke (4.1%; 95% CI, 4.0%-4.2%), aortic dissection (4.5%; 95% CI, 3.9%-5.1%), and SAH (3.5%; 95% CI, 3.1%-3.9%). Longitudinal trends were either nonsignificant (AMI and aortic dissection) or increasing (ruptured AAA, stroke, and SAH). Patient characteristics associated with unrecognized emergencies included age younger than 65 years, dual eligibility for Medicare and Medicaid coverage, female sex, and each of the following chronic conditions: end-stage renal disease, dementia, depression, diabetes, cerebrovascular disease, hypertension, coronary artery disease, and chronic obstructive pulmonary disease.
Among Medicare patients, opportunities to diagnose ruptured AAA, AMI, stroke, aortic dissection, and SAH are missed in less than 1 in 20 ED presentations. Further improvement may prove difficult.
美国国家医学院将诊断错误描述为患者安全的下一个前沿领域,并强调了对更好的测量工具的迫切需求。
估计因即将破裂的腹主动脉瘤(AAA)、急性心肌梗死(AMI)、中风、主动脉夹层和蛛网膜下腔出血(SAH)而导致的急诊科(ED)就诊的比例,这些就诊最终未确诊即出院;评估纵向趋势;并确定与错过诊断机会相关的患者特征。
设计、地点和参与者:这是一项针对 2006 年至 2014 年所有医疗保险索赔的回顾性队列研究。研究地点是美国医院的急诊科。参与者包括 2007 年至 2014 年期间因所关注病症住院的所有医疗保险收费服务患者。排除临终关怀注册患者和最近在熟练护理机构住院的患者。
使用观察到的 ED 45 天内出院人数与预期 ED 出院人数之间的差异来估计潜在诊断机会的漏诊率,将预期出院人数作为分母,以同一患者在更早月份的 ED 使用情况为基础。将分母估计为识别出的紧急情况(住院入院)加上未识别出的紧急情况(超额出院)的数量。
共有 1561940 名患者,包括 17963 名因破裂性 AAA 住院、304980 名因 AMI 住院、1181648 名因中风住院、19675 名因主动脉夹层住院和 37674 名因 SAH 住院。平均(SD)年龄为 77.9(10.3)岁;8.9%的患者年龄小于 65 岁,54.1%的患者为女性。ED 漏诊的诊断机会比例如下:破裂性 AAA(3.4%;95%CI,2.9%-4.0%)、AMI(2.3%;95%CI,2.1%-2.4%)、中风(4.1%;95%CI,4.0%-4.2%)、主动脉夹层(4.5%;95%CI,3.9%-5.1%)和蛛网膜下腔出血(3.5%;95%CI,3.1%-3.9%)。纵向趋势要么不显著(AMI 和主动脉夹层),要么呈上升趋势(破裂性 AAA、中风和蛛网膜下腔出血)。与未识别出的紧急情况相关的患者特征包括年龄小于 65 岁、医疗保险和医疗补助的双重资格、女性性别以及以下任何一种慢性疾病:终末期肾病、痴呆、抑郁症、糖尿病、脑血管疾病、高血压、冠心病和慢性阻塞性肺疾病。
在医疗保险患者中,不到 1/20 的 ED 就诊机会未能诊断出破裂性 AAA、AMI、中风、主动脉夹层和蛛网膜下腔出血。进一步的改善可能很困难。