Gustafsson H C, Grieve P G, Werner E A, Desai P, Monk C
1Department of Psychiatry,Oregon Health and Science University,Portland,OR,USA.
2Department of Pediatrics,Columbia University Medical Center,New York,NY,USA.
J Dev Orig Health Dis. 2018 Aug;9(4):381-385. doi: 10.1017/S2040174418000089. Epub 2018 Mar 6.
Maternal perinatal depression exerts pervasive effects on the developing brain, as evidenced by electroencephalographic (EEG) patterns that differ between children of women who do and do not meet DSM or ICD diagnostic criteria. However, little research has examined if the same EEG pattern of right-frontal alpha asymmetry exists in newborns and thus originates in utero independent of postnatal influences, and if depressive symptoms are associated with this neural signature. Utilizing 125-lead EEG (n=18), this study considered clinician-rated maternal prenatal depressive symptoms in relation to newborn EEG. Maternal depressive symptomatology was associated with greater relative right-frontal alpha asymmetry during quiet sleep. These results suggest that even subclinical levels of maternal depression may influence infant brain development, and further support the role of the prenatal environment in shaping children's future neurobehavioral trajectories.
围产期母亲抑郁对发育中的大脑有广泛影响，这一点从符合和不符合《精神疾病诊断与统计手册》（DSM）或《国际疾病分类》（ICD）诊断标准的女性所生子女之间不同的脑电图（EEG）模式中得到了证明。然而，很少有研究探讨新生儿是否存在相同的右额叶阿尔法不对称脑电图模式，以及这种模式是否在子宫内就已形成，独立于产后影响，同时也很少有研究探讨抑郁症状是否与这种神经特征有关。本研究利用125导联脑电图（n = 18），考察了临床医生评定的母亲产前抑郁症状与新生儿脑电图之间的关系。母亲的抑郁症状与安静睡眠期间相对更大的右额叶阿尔法不对称有关。这些结果表明，即使是母亲抑郁的亚临床水平也可能影响婴儿大脑发育，并进一步支持产前环境在塑造儿童未来神经行为轨迹中的作用。
