一种新型大环内酯类药物A-56268与罗红霉素、红霉素及克林霉素的体外活性比较
In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin, and clindamycin.
作者信息
Barry A L, Thornsberry C, Jones R N
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):343-5. doi: 10.1128/AAC.31.2.343.
Abstract
A new macrolide (A-56268) was found to be approximately twice as active as erythromycin and four to eight times more active than roxithromycin. All three macrolides were similar in their potency against anaerobes. Human plasma enhanced the antistaphylococcal activity of A-56268 and erythromycin but reduced the activities of roxithromycin and clindamycin.
摘要
一种新的大环内酯类药物（A - 56268）的活性约为红霉素的两倍，比罗红霉素高4至8倍。这三种大环内酯类药物对厌氧菌的效力相似。人血浆增强了A - 56268和红霉素的抗葡萄球菌活性，但降低了罗红霉素和克林霉素的活性。
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