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2
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本文引用的文献

1
Effect of carbon dioxide and pH on susceptibility of Bacteroides fragilis group to erythromycin.二氧化碳和pH值对脆弱拟杆菌群对红霉素敏感性的影响。
Antimicrob Agents Chemother. 1981 Feb;19(2):335-6. doi: 10.1128/AAC.19.2.335.
2
In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria.新型大环内酯类药物RU 28965与红霉素对需氧菌和厌氧菌活性的体外比较。
Antimicrob Agents Chemother. 1984 Apr;25(4):529-31. doi: 10.1128/AAC.25.4.529.
3
In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs.三种新型大环内酯类抗菌剂RU28965、RU29065和RU29702的体外评价及与其他口服药物的比较。
Antimicrob Agents Chemother. 1983 Aug;24(2):209-15. doi: 10.1128/AAC.24.2.209.
4
Effect of several components of anaerobic incubation on antibiotic susceptibility test results.
Antimicrob Agents Chemother. 1972 May;1(5):433-40. doi: 10.1128/AAC.1.5.433.
5
Erythromycin: a microbial and clinical perspective after 30 years of clinical use (1).红霉素：临床应用30年后的微生物学及临床视角（1）
Mayo Clin Proc. 1985 Mar;60(3):189-203. doi: 10.1016/s0025-6196(12)60219-5.
6
In vitro activity of the new macrolide antibiotic roxithromycin (RU 28965) against clinical isolates of Haemophilus influenzae.新型大环内酯类抗生素罗红霉素（RU 28965）对流感嗜血杆菌临床分离株的体外活性
Antimicrob Agents Chemother. 1986 May;29(5):921-2. doi: 10.1128/AAC.29.5.921.
7
In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide.新型大环内酯类药物A-56268（TE-031）的体外和体内评估
Antimicrob Agents Chemother. 1986 Dec;30(6):865-73. doi: 10.1128/AAC.30.6.865.
8
Aerobically incubated thioglycolate broth disk method for antibiotic susceptibility testing of anaerobes.用于厌氧菌抗生素敏感性测试的需氧培养硫乙醇酸盐肉汤纸片法。
Antimicrob Agents Chemother. 1976 Oct;10(4):727-32. doi: 10.1128/AAC.10.4.727.
9
In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae.蔷薇霉素、交沙霉素、红霉素和克林霉素对淋病奈瑟菌β-内酰胺酶阴性和β-内酰胺酶阳性菌株的体外活性。
Antimicrob Agents Chemother. 1979 Feb;15(2):243-5. doi: 10.1128/AAC.15.2.243.

一种新型大环内酯类药物A-56268与罗红霉素、红霉素及克林霉素的体外活性比较

In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin, and clindamycin.

作者信息

Barry A L, Thornsberry C, Jones R N

出版信息

Antimicrob Agents Chemother. 1987 Feb;31(2):343-5. doi: 10.1128/AAC.31.2.343.

DOI:10.1128/AAC.31.2.343
PMID:2952064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174723/
Abstract

A new macrolide (A-56268) was found to be approximately twice as active as erythromycin and four to eight times more active than roxithromycin. All three macrolides were similar in their potency against anaerobes. Human plasma enhanced the antistaphylococcal activity of A-56268 and erythromycin but reduced the activities of roxithromycin and clindamycin.

摘要

一种新的大环内酯类药物（A - 56268）的活性约为红霉素的两倍，比罗红霉素高4至8倍。这三种大环内酯类药物对厌氧菌的效力相似。人血浆增强了A - 56268和红霉素的抗葡萄球菌活性，但降低了罗红霉素和克林霉素的活性。