School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR China.
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, PR China.
Immunol Lett. 2018 May;197:70-77. doi: 10.1016/j.imlet.2018.03.006. Epub 2018 Mar 14.
Live bacteria, including attenuated bacteria and probiotics, can be engineered to deliver target antigen to excite the host immune system. The preponderance of these live bacterial vaccine vectors is that they can stimulate durable humoral and cellular immunity. Moreover, delivery strategies of heterologous antigen in live bacterial promote the applications of new vaccine development. Genetic technologies are evolving, which potentiate the developing of heterologous antigen delivery systems, including bacterial surface display system, bacterial secretion system and balanced lethal vector system. Although the live bacterial vaccine vector is a powerful adjuvant, certain disadvantages, such as safety risk, must also be taken into account. In this review, we compare the development of representative live bacterial vectors, and summarize the main characterizations of the various delivery strategies of heterologous antigen in live vector vaccines.
活细菌，包括减毒细菌和益生菌，可以被设计用来将目标抗原传递给宿主以激发免疫系统。这些活细菌疫苗载体的主要优势在于它们可以刺激持久的体液和细胞免疫。此外，活细菌中异源抗原的传递策略促进了新疫苗开发的应用。遗传技术正在不断发展，这为异源抗原传递系统的开发提供了可能，包括细菌表面展示系统、细菌分泌系统和平衡致死载体系统。尽管活细菌疫苗载体是一种强大的佐剂，但也必须考虑到某些缺点，如安全风险。在这篇综述中，我们比较了有代表性的活细菌载体的发展，并总结了活载体疫苗中异源抗原传递策略的主要特点。
