Department of Sports Dietetics, Chair of Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland.
Department of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806, Poznan, Poland.
Sci Rep. 2024 Feb 12;14(1):3525. doi: 10.1038/s41598-024-54100-1.
This study was conducted in two groups of girls with PCOS (polycystic ovary syndrome) categorized as slim (group N) and overweight-to-obese (group Ov/Ob). The study's primary outcome was to assess the impact of a 12-week anti-inflammatory diet (AIDiet) intervention, without energy deficit, on daily diet quality improvement, evaluated according to the KIDMED index. The secondary outcome was improving inflammatory, redox, hormonal, and metabolic statuses. In the study, which was completed by 13 girls from the Ov/Ob group and 19 girls from the N group, a significant improvement in the mean KIDMED score was obtained. Moreover, the intervention significantly improves concentration of total antioxidant capacity (TAC), fasting insulin, and the homeostatic model assessment for insulin resistance (HOMA-IR) index, in the Ov/Ob group, while both groups experienced a reduction in the concentration of interleukin (IL)-1 and IL-6, tumour necrosis factor (TNF-α), and androstenedione. The AIDiet intervention effectively improved the quality of the subjects' diets, which was associated with the improvement of hormonal and immuno-metabolic markers. However, these changes in normal-weight patients were observed regardless of body weight reduction. ClinicalTrials.gov Identifier NCT04738409.
本研究将多囊卵巢综合征（PCOS）女孩分为两组，即苗条（N 组）和超重/肥胖（Ov/Ob 组）。研究的主要结果是评估无能量不足的 12 周抗炎饮食（AIDiet）干预对根据 KIDMED 指数评估的日常饮食质量改善的影响。次要结果是改善炎症、氧化还原、激素和代谢状态。在这项研究中，Ov/Ob 组有 13 名女孩和 N 组有 19 名女孩完成了研究，结果显示 KIDMED 评分的平均值显著提高。此外，干预显著改善了 Ov/Ob 组的总抗氧化能力（TAC）、空腹胰岛素和胰岛素抵抗的稳态模型评估（HOMA-IR）指数，而两组的白细胞介素（IL）-1 和 IL-6、肿瘤坏死因子（TNF-α）和雄烯二酮浓度均降低。AIDiet 干预有效地改善了受试者的饮食质量，这与激素和免疫代谢标志物的改善有关。然而，无论体重减轻与否，正常体重患者都观察到这些变化。ClinicalTrials.gov 标识符 NCT04738409。
