Mahasneh Sari A, Mahasneh Adel M
School of Dental Medicine, The University of Manchester, Manchester, M13 9PL, UK.
Department of Biological Sciences, The University of Jordan, Amman 11942, Jordan.
Dent J (Basel). 2017 Sep 27;5(4):26. doi: 10.3390/dj5040026.
Probiotics have a role in maintaining oral health through interaction with oral microbiome, thus contributing to healthy microbial equilibrium. The nature and composition of any individual microbiome impacts the general health, being a major contributor to oral health. The emergence of drug resistance and the side effects of available antimicrobials have restricted their use in an array of prophylactic options. Indeed, some new strategies to prevent oral diseases are based on manipulating oral microbiota, which is provided by probiotics. Currently, no sufficient substantial evidence exists to support the use of probiotics to prevent, treat or manage oral cavity diseases. At present, probiotic use did not cause adverse effects or increased risks of caries or periodontal diseases. This implicates no strong evidence against treatment using probiotics. In this review, we try to explore the use of probiotics in prevention, treatment and management of some oral cavity diseases and the possibilities of developing designer probiotics for the next generation of oral and throat complimentary healthcare.
益生菌通过与口腔微生物群相互作用在维持口腔健康方面发挥作用,从而有助于实现健康的微生物平衡。任何个体微生物群的性质和组成都会影响总体健康,是口腔健康的主要贡献因素。耐药性的出现以及现有抗菌药物的副作用限制了它们在一系列预防选择中的应用。事实上,一些预防口腔疾病的新策略基于对口腔微生物群的调控,而益生菌可以提供这种调控。目前,没有足够的实质性证据支持使用益生菌来预防、治疗或管理口腔疾病。目前,使用益生菌并未导致不良反应或增加龋齿或牙周疾病的风险。这意味着没有强有力的证据反对使用益生菌进行治疗。在本综述中,我们试图探讨益生菌在一些口腔疾病的预防、治疗和管理中的应用,以及开发用于下一代口腔和咽喉辅助保健的定制益生菌的可能性。