Ludlow C L, Connor N P, Bassich C J
Speech Pathology Unit, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20205.
Brain Lang. 1987 Nov;32(2):195-214. doi: 10.1016/0093-934x(87)90124-6.
The purpose was to determine the effects of two different basal ganglia diseases on speech planning, initiation, and production. Patients with Parkinson's Disease (PD) and Huntington's Disease (HD) were compared with normal subjects on speech timing tasks. Speech reaction time was unimpaired, while changes in duration at different speech rates were affected differently in the two patient groups. In HD, changes in the duration of syllables, of pauses between phrases, and of sentences were all reduced, while in PD only the control of sentence duration was impaired. The HD patients had reduced syllable repetition rates, but both patient groups maintained their repetition rates over 5 sec. The ratios of word to phrase time, and of phrase to sentence time, remained constant across regular and fast speaking rates and did not differ from normal in either patient group. The results suggest that PD and HD patients are not impaired in speech planning or initiation, but have poor control over the duration of speech events.
目的是确定两种不同的基底神经节疾病对言语计划、启动和产生的影响。将帕金森病（PD）患者和亨廷顿病（HD）患者与正常受试者进行言语计时任务比较。言语反应时间未受损，而在不同语速下持续时间的变化在两组患者中受到的影响不同。在HD中，音节持续时间、短语间停顿持续时间和句子持续时间的变化均减少，而在PD中，仅句子持续时间的控制受损。HD患者的音节重复率降低，但两组患者在5秒以上均保持其重复率。在正常语速和快速语速下，词与短语时间之比以及短语与句子时间之比保持恒定，且两组患者与正常情况均无差异。结果表明，PD和HD患者在言语计划或启动方面未受损，但对言语事件的持续时间控制不佳。
