Penigrisacids A-D，四种新型倍半萜类化合物，来自深海来源的.
Penigrisacids A-D, Four New Sesquiterpenes from the Deep-Sea-Derived .
机构信息
Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 361021, China.
出版信息
Mar Drugs. 2019 Aug 29;17(9):507. doi: 10.3390/md17090507.
Four new (penigrisacids A-D, -) and one known () carotane sesquiterpenoids were isolated from the deep-sea-derived fungus , along with four known compounds (-). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value. Compound exhibited potent anti-food allergic activity with IC value of 28.7 μM, while showed weak cytotoxicity against ECA-109 tumor cells (IC = 28.7 μM).
从深海来源的真菌 Penicillium sp. 中分离得到了四个新的（penigrisacids A-D，-）和一个已知的（）胡萝卜烷倍半萜，以及四个已知的化合物（-）。通过对 NMR 和 HRESIMS 数据的广泛分析，确定了新化合物的平面结构和相对构型。通过比较实验和计算的 ECD（电子圆二色性）光谱或 OR（旋光）值确定了绝对构型。化合物 表现出强烈的抗食物过敏活性，IC 值为 28.7 μM，而 对 ECA-109 肿瘤细胞表现出较弱的细胞毒性（IC = 28.7 μM）。
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