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磁共振粒子成像中示踪剂分布与本底的联合重建

Joint Reconstruction of Tracer Distribution and Background in Magnetic Particle Imaging.

出版信息

IEEE Trans Med Imaging. 2018 May;37(5):1192-1203. doi: 10.1109/TMI.2017.2777878.


DOI:10.1109/TMI.2017.2777878
PMID:29727282
Abstract

Magnetic particle imaging (MPI) is a novel tomographic imaging technique, which visualizes the distribution of a magnetic nanoparticle-based tracer material. However, reconstructed MPI images often suffer from an insufficiently compensated image background caused by rapid non-deterministic changes in the background signal of the imaging device. In particular, the signal-to-background ratio (SBR) of the images is reduced for lower tracer concentrations or longer acquisitions. The state-of-the-art procedure in MPI is to frequently measure the background signal during the sample measurement. Unfortunately, this requires a removal of the entire object from the scanner's field of view (FOV), which introduces dead time and repositioning artifacts. To overcome these considerable restrictions, we propose a novel method that uses two consecutive image acquisitions as input parameters for a simultaneous reconstruction of the tracer distribution, as well as the background signal. The two acquisitions differ by just a small spatial shift, while keeping the object always within the focus of a slightly reduced FOV. A linearly interpolated background between the initial and final background measurement is used to seed the iterative reconstruction. The method has been tested with simulations and phantom measurements. Overall, a substantial reduction of the image background was observed, and the image SBR is increased by a factor of 2(7) for the measurement (simulation) data.

摘要

磁性粒子成像(MPI)是一种新型的层析成像技术,可用于可视化基于磁性纳米粒子示踪剂材料的分布。然而,重建的 MPI 图像通常会受到成像设备背景信号快速变化而导致的补偿不足的影响。特别是,对于较低的示踪剂浓度或更长的采集时间,图像的信号背景比(SBR)会降低。MPI 中的最新方法是在样本测量过程中频繁测量背景信号。不幸的是,这需要将整个物体从扫描仪的视野(FOV)中移出,这会引入死时间和重新定位伪影。为了克服这些相当大的限制,我们提出了一种新方法,该方法使用两次连续的图像采集作为示踪剂分布以及背景信号的同时重建的输入参数。两次采集仅在空间上有微小的偏移,同时使物体始终保持在稍微减小的 FOV 的焦点内。在线性内插初始和最终背景测量之间的背景用于为迭代重建播种。该方法已通过模拟和体模测量进行了测试。总体而言,观察到图像背景的大幅降低,并且对于测量(模拟)数据,图像 SBR 增加了 2(7)倍。

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引用本文的文献

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[2]
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[4]
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[5]
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[6]
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