Program of Human Nutrition, 1787 Neil Avenue, 302 Campbell Hall, The Ohio State University, Columbus, OH 43210, USA.
OSU Nutrition Graduate Program, Graduate School, The Ohio State University, Columbus, OH 43210, USA.
Prostaglandins Leukot Essent Fatty Acids. 2018 May;132:30-33. doi: 10.1016/j.plefa.2018.03.001. Epub 2018 Apr 7.
Dietary fat quality, especially the intake of specific types of fatty acids, impacts the risk of many chronic diseases, including cardiovascular diseases, certain cancers and type 2 diabetes (T2DM). A recent pooled analysis involving 20 studies from around the world revealed that higher linoleic acid (18:2n-6 LA) biomarker is associated with dose-dependent decreases in the incidence of T2DM. This latest study corroborates earlier cross-sectional studies and intervention trials showing that biomarkers of LA intake are associated with reduced risk of T2DM and better glycemic control and/or insulin sensitivity. This review highlights key clinical trials that have evaluated the role of LA in glycemia and the related condition, insulin sensitivity.
饮食中的脂肪质量，尤其是特定类型脂肪酸的摄入，会影响许多慢性疾病的风险，包括心血管疾病、某些癌症和 2 型糖尿病（T2DM）。最近一项涉及全球 20 项研究的汇总分析表明，较高的亚油酸（18:2n-6 LA）生物标志物与 T2DM 发病率呈剂量依赖性下降相关。这项最新研究证实了早期的横断面研究和干预试验，表明 LA 摄入量的生物标志物与 T2DM 风险降低以及更好的血糖控制和/或胰岛素敏感性相关。这篇综述强调了评估 LA 在血糖和相关疾病胰岛素敏感性中的作用的关键临床试验。
