验证西雅图心绞痛问卷在缺血性心脏病女性患者中的应用。
Validation of the Seattle angina questionnaire in women with ischemic heart disease.
机构信息
University of Missouri- Kansas City, Kansas City, MO; Saint Luke's Mid America Heart Institute, Kansas City, MO.
University of Missouri- Kansas City, Kansas City, MO; Saint Luke's Mid America Heart Institute, Kansas City, MO.
出版信息
Am Heart J. 2018 Jul;201:117-123. doi: 10.1016/j.ahj.2018.04.012. Epub 2018 Apr 21.
BACKGROUND
Although the Seattle Angina Questionnaire (SAQ) has been widely used to assess disease-specific health status in patients with ischemic heart disease, it was originally developed in a predominantly male population and its validity in women has been questioned.
METHODS
Using data from 8892 men and 4013 women across 2 multicenter trials and 5 registries, we assessed the construct validity, test-retest reliability, responsiveness to clinical change, and predictive validity of the SAQ Summary Score (SS) and its 5 subdomains (Physical Limitation (PL), Anginal Stability (AS), Angina Frequency (AF), Treatment Satisfaction (TS), and Quality of Life (QoL)) separately in men and women.
RESULTS
Comparable correlations of the SAQ SS with Canadian Cardiovascular Society class was demonstrated in both men and women (-0.48 for men, -0.46 for women). Similar correlations between the SAQ PL scale with treadmill exercise duration and Short Form-12 (SF-12) Physical Component Summary were observed in women and men (0.34-0.63 and 0.40-0.63, respectively). SAQ AS scores were significantly lower for both men and women with acute syndromes compared with 1 month later. The SAQ AF scale was strongly correlated with daily angina diaries (0.62 for men and 0.66 for women). The SAQ QoL scores were moderately correlated with the EQ5D visual analog scale and SF-12 general health question in men (0.43-0.50) and women (0.33-0.39). All SAQ scales demonstrated excellent reliability (intraclass correlation ≥0.78) in both men and women with stable CAD and were very sensitive to change after percutaneous coronary intervention (≥15-point difference in scores, standardized response mean ≥ 0.67). The SAQ SS was similarly predictive of 1-year mortality and cardiac re-hospitalizations for both men and women.
CONCLUSION
The SAQ demonstrates similar psychometric properties in men and women with CAD. These findings provide evidence for validity of the SAQ in assessing women with IHD.
背景
西雅图心绞痛问卷（SAQ）已广泛用于评估缺血性心脏病患者的特定疾病健康状况，但最初是在男性人群中开发的，其在女性中的有效性受到质疑。
方法
我们使用来自 2 项多中心试验和 5 项注册研究的 8892 名男性和 4013 名女性的数据，分别评估了 SAQ 综合评分（SS）及其 5 个亚领域（身体限制（PL）、稳定性心绞痛（AS）、心绞痛频率（AF）、治疗满意度（TS）和生活质量（QoL））在男性和女性中的结构有效性、重测信度、对临床变化的反应能力和预测有效性。
结果
在男性和女性中，SAQ SS 与加拿大心血管学会（CCS）分级的相关性相似（男性为-0.48，女性为-0.46）。在女性和男性中，SAQ PL 量表与跑步机运动时间和 SF-12 物理成分综合评分之间也观察到相似的相关性（分别为 0.34-0.63 和 0.40-0.63）。与 1 个月后相比，急性综合征的男性和女性的 SAQ AS 评分均显著降低。SAQ AF 量表与每日心绞痛日记密切相关（男性为 0.62，女性为 0.66）。SAQ QoL 评分与男性的 EQ5D 视觉模拟量表和 SF-12 一般健康问题呈中度相关（男性为 0.43-0.50，女性为 0.33-0.39）。在患有稳定 CAD 的男性和女性中，所有 SAQ 量表的可靠性均很高（组内相关系数≥0.78），经皮冠状动脉介入治疗后变化非常敏感（评分差异≥15 分，标准化反应均值≥0.67）。SAQ SS 对男性和女性的 1 年死亡率和心脏再入院率也具有相似的预测价值。
结论
SAQ 在 CAD 男性和女性中具有相似的心理测量特性。这些发现为 SAQ 在评估女性缺血性心脏病中的有效性提供了证据。
Zotero 插件