Sethi Seema, Sethi Sajiv, Bluth Martin H
Department of Pathology, University of Michigan and VA Hospital, E300, 2215 Fuller Road, Ann Arbor, MI 48105, USA.
Department of Gastroenterology, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 82, Tampa, FL 33612, USA.
Clin Lab Med. 2018 Jun;38(2):237-251. doi: 10.1016/j.cll.2018.02.003.
MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provide cancer-specific personalized therapy.
微小RNA（miRNA）有望为包括恶性肿瘤在内的多种疾病提供诊断、预后和治疗靶点，以用于精准医学应用。miRNA在临床领域具有巨大潜力，因为它们可以在血液、血清、组织（新鲜的和福尔马林固定石蜡包埋的）以及细针穿刺标本中被检测到。基于miRNA的治疗最吸引人的特点是单个miRNA可能对靶向癌症中多个失调基因有用，这可以通过系统生物学和网络分析进一步研究，而系统生物学和网络分析可能会提供癌症特异性的个性化治疗。
