D'Acunto Mario
Consiglio Nazionale delle Ricerche, Istituto di Biofisica, CNR-IBF, via Moruzzi 1, 56124 Pisa, Italy.
Materials (Basel). 2018 May 24;11(6):882. doi: 10.3390/ma11060882.
Photothermal therapy (PTT) takes advantage of unique properties of gold nanoparticles (AuNPs) (nanospheres, nanoshells (AuNSs), nanorods (AuNRs)) to destroy cancer cells or tumor tissues. This is made possible thanks principally to both to the so-called near-infrared biological transparency window, characterized by wavelengths falling in the range 700⁻1100 nm, where light has its maximum depth of penetration in tissue, and to the efficiency of cellular uptake mechanisms of AuNPs. Consequently, the possible identification of intracellular AuNPs plays a key role for estimating the effectiveness of PTT treatments. Here, we review the recognized detection techniques of such intracellular probes with a special emphasis to the exploitation of near-infrared biological transparency window.
光热疗法（PTT）利用金纳米颗粒（AuNPs）（纳米球、纳米壳（AuNSs）、纳米棒（AuNRs））的独特性质来破坏癌细胞或肿瘤组织。这主要得益于所谓的近红外生物透明窗口，其特征在于波长范围为700 - 1100nm，在此范围内光在组织中的穿透深度最大，以及AuNPs的细胞摄取机制的效率。因此，细胞内金纳米颗粒的可能识别对于评估PTT治疗的有效性起着关键作用。在此，我们回顾了此类细胞内探针的公认检测技术，并特别强调对近红外生物透明窗口的利用。
