水中氯对艾柯病毒的病毒粒子构象形式及复杂失活动力学
Virion conformational forms and the complex inactivation kinetics of echovirus by chlorine in water.
作者信息
Young D C, Sharp D G
出版信息
Appl Environ Microbiol. 1985 Feb;49(2):359-64. doi: 10.1128/aem.49.2.359-364.1985.
Abstract
Aberrant inactivation kinetics were observed when monodispersed echovirus type 1 (Farouk) was inactivated with chlorine. An initial 1- to 2-log10-unit decrease in titer was followed by lag period, during which the titer stayed the same or increased, and this was followed by a final decline in titer. First-order kinetics were obtained with poliovirus type 1 under the same conditions. Isoelectric focusing studies of echovirus before chlorine treatment showed that the virus distributed into two pH-dependent and interconvertible isoelectric forms. After chlorine treatment all remaining virus infectivity was associated with a third pH-independent isoelectric form. The complex inactivation kinetics appeared to be due to shifts between these conformational forms during inactivation in certain ionic environments. Under certain conditions the conformational shifts resulted in substantial resistance of monodispersed echovirus to chlorine.
摘要
当用氯灭活单分散的1型艾柯病毒（法鲁克株）时，观察到异常的失活动力学。最初滴度下降1至2个对数10单位，随后是一个停滞期，在此期间滴度保持不变或上升，接着是滴度的最终下降。在相同条件下，1型脊髓灰质炎病毒呈现一级动力学。氯处理前对艾柯病毒的等电聚焦研究表明，该病毒分布为两种pH依赖性且可相互转化的等电形式。氯处理后，所有剩余的病毒感染性都与第三种不依赖pH的等电形式相关。复杂的失活动力学似乎是由于在某些离子环境中灭活过程中这些构象形式之间的转变所致。在某些条件下，构象转变导致单分散的艾柯病毒对氯具有显著抗性。
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本文引用的文献
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